301662-76-0Relevant academic research and scientific papers
A cyclooligomerisation approach to backbone-modified cyclic peptides bearing guanidinium arms
Black, Richard J.G.,Dungan, Victoria J.,Li, Rebecca Y.T.,Young, Philip G.,Jolliffe, Katrina A.
supporting information; experimental part, p. 551 - 554 (2010/09/18)
Cyclooligomerisation of the pentafluorophenyl ester derivatives of oxazoles, derived from dipeptides containing protected ornithine, diaminobutanoic acid and diaminopropionic acid residues, gives the cyclic trimers as the major products. Deprotection and treatment with guanidinylating agents provides efficient access to backbone rigidified cyclic peptides with guanidinium functionalised side chains. Georg Thieme Verlag Stuttgart.
Functionalized platforms based on marine cyclopeptides: Different pathways to the hexapeptide
Boss,Rasmussen,Wartini,Waldvogel
, p. 6327 - 6331 (2007/10/03)
The synthesis of macrocyclic, roughly planar, exclusively syn-functionalized hexapeptides, related to dolastatin I and bistratamide C from enantiomerically pure oxazole precursors is reported. The platforms can either be synthesized in a stepwise procedure by final cyclization of the linear oxazole trimers or in a direct 'one-pot' reaction. The investigation on the coupling of these building blocks into linear dimers and trimers with modern peptide coupling reagents is reported. (C) 2000 Published by Elsevier Science Ltd.
