301677-62-3Relevant academic research and scientific papers
Inhibitors of bacterial tyrosyl tRNA synthetase: Synthesis of four stereoisomeric analogues of the natural product SB-219383
Berge, John M.,Copley, Royston C.B.,Eggleston, Drake S.,Hamprecht, Dieter W.,Jarvest, Richard L.,Mensah, Lucy M.,O'Hanlon, Peter J.,Pope, Andrew J.
, p. 1811 - 1814 (2000)
Synthetic analogues of the microbial metabolite SB-219383 have been synthesised with defined stereochemistry. Densely functionalised hydroxylamine containing amino acids were prepared by the addition of a glycine anion equivalent to sugar-derived cyclic nitrones. One of four stereoisomeric dipeptides incorporating these novel amino acids was found to be a potent and selective inhibitor of bacterial tyrosyl tRNA synthetase, suggesting analogous stereochemistry of the natural product. (C) 2000 Elsevier Science Ltd. All rights reserved.
