301684-97-9Relevant academic research and scientific papers
Antimicrobial agents
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Page column 15, (2010/11/30)
Compounds of formula (I) are antibacterial agents: wherein Z represents a radical of formula —N(OH)CH(=O) or of formula —C(=O)NH(OH), and R1-R4 are as defined in the specification. A method for the treatment of bacterial or protozoal infections in humans and non-human mammals, which comprises administering to a subject suffering such infection an antibacterially or antiprotozoally effective dose of a compound of formula (I) or a pharmaceutically or veterinarily acceptable salt, hydrate or solvate thereof.
Peptide deformylase inhibitors with activity against respiratory tract pathogens
East, Stephen P.,Beckett, R. Paul,Brookings, Daniel C.,Clements, John M.,Doel, Sheila,Keavey, Kenneth,Pain, Gilles,Smith, Helen K.,Thomas, Wayne,Thompson, Alison J.,Todd, Richard S.,Whittaker, Mark
, p. 59 - 62 (2007/10/03)
A series of analogues of the peptide deformylase (PDF) inhibitor BB-3497 where the P3′ amide bond was replaced with a ketone functionality is described. The in vitro antibacterial profiling of these compounds revealed that they demonstrate activity agains
