301698-41-9Relevant academic research and scientific papers
Copper-Catalyzed [4 + 1] Annulation between α-Hydroxy Ketones and Nitriles: An Approach to Highly Substituted 3(2H)-Furanones
He, Haitao,Qi, Chaorong,Hu, Xiaohan,Lu, Ouyang,Xiong, Wenfang,Jiang, Huanfeng
, p. 4957 - 4965 (2015)
A copper-catalyzed [4 + 1] annulation between α-hydroxy ketones and nitriles has been developed. The reaction provides a facile and efficient method for the construction of a wide range of highly substituted 3(2H)-furanones, a class of important compounds
4,5-diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors
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, (2008/06/13)
The present invention provides a novel class of 4,5-diaryl-3(2H)-furanone derivatives, which inhibit strongly and selectively COX-2 over COX-1. They are useful to treat inflammation, inflammation-associated disorders, and COX-2 mediated diseases.
