30170-60-6Relevant academic research and scientific papers
Diastereoselective synthesis of indanes and tetralins via intramolecular Friedel-Crafts reaction
Begouin, Jeanne-Marie,Capitta, Francesca,Wu, Xian,Niggemann, Meike
, p. 1370 - 1373 (2013)
An easy access to tetralin and indane skeletons has been developed using a diastereoselective intramolecular Friedel-Crafts alkylation. Treatment of diastereomeric mixtures of benzyl carbinols with a catalytic amount of Ca(NTf2)2/Bu4NPF6 yields the respective tetralin or indane in good yields with high levels of regio- and diastereoselectivity.
