301700-16-3Relevant academic research and scientific papers
NOVEL INDOLINONE DERIVATIVES
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Page/Page column 45-46, (2008/06/13)
The invention relates to novel indolinone derivatives of formula I wherein X, Ri, R2, R3, R4, Rs, Re, Ri', FV/ FV/ IV and R5' are as shown herein as well as their use in the treatment of inflammatory autoimmune diseases such as multiple sclerosis, in part
New routes to oxindole derivatives
Porcs-Makkay, Marta,Volk, Balazs,Kapiller-Dezsoefi, Rita,Mezei, Tibor,Simig, Gyula
, p. 697 - 711 (2007/10/03)
A new, practical synthesis of the antirheumatic oxindole derivative, tenidap, has been elaborated. The new approach has initiated studies on the mechanism of the acylation reactions of oxindoles. Methods have been developed for the synthesis of 1-[alkoxy(or aryloxy)carbonyl]- and 1,3-di[alkoxy(or aryloxy)carbonyl]oxindoles starting from oxindoles. The route designed for tenidap has provided a facile access to several analogues, too. On another front, new reaction conditions are described, which turn Wenkert's synthesis of 3-alkyloxindoles (by Raney nickel induced alkylation of oxindoles with alcohols) into a highly efficient synthetic tool. The method has been extended to the synthesis of 3-alkyloxindoles from isatins and to the preparation of 3-(ω-hydroxyalkyl)oxindoles from oxindoles and isatins. Springer-Verlag 2004.
Synthesis of 1,3-di[alkoxy(aryloxy)carbonyl]-2-oxo-2,3-dihydroindoles
Porcs-Makkay, Márta,Argay, Gyula,Kálmán, Alajos,Simig, Gyula
, p. 5893 - 5903 (2007/10/03)
Two protocols have been developed for the synthesis of 1,3-di[alkoxy(aryloxy)carbonyl]-2-oxo-2,3-dihydroindoles starting from the corresponding N,O-diacyl derivatives obtained by treatment of 2-oxindoles with chloroformic acid esters and triethylamine. Th
