3018-68-6

Usage

Uses

Used in Oncology Applications:
2-METHYL-1-PHENYL-1H-BENZIMIDAZOL-5-AMINE HYDROCHLORIDE is used as a potential antineoplastic agent for its ability to inhibit the growth of cancer cells. It has shown promise in the field of oncology, with studies demonstrating its potential to be a valuable compound in the development of new cancer treatments.
Used in Antimicrobial Applications:
2-METHYL-1-PHENYL-1H-BENZIMIDAZOL-5-AMINE HYDROCHLORIDE is used as a potential antimicrobial agent, with investigations into its ability to combat various types of infections caused by bacteria and other microorganisms.
Used in Pharmaceutical and Research Applications:
2-METHYL-1-PHENYL-1H-BENZIMIDAZOL-5-AMINE HYDROCHLORIDE is used as a crystalline solid that is soluble in water and organic solvents, making it suitable for various pharmaceutical formulations and research purposes, including drug development and medicinal chemistry studies.

InChI:InChI=1/C14H13N3/c1-10-16-13-9-11(15)7-8-14(13)17(10)12-5-3-2-4-6-12/h2-9H,15H2,1H3

Upstream product

• 14625-61-7 2-methyl-5-nitro-1-phenyl-1H-benzo[d]imidazole 
• 860577-20-4 acetic acid-(5-amino-2-anilino-anilide) 
• 136-17-4 2,4-diaminodiphenylamine 
• 108-24-7 acetic anhydride 
• 156118-85-3 N,N'-(4-anilino-m-phenylene)-bis-acetamide 
• 961-68-2 N-phenyl-2,4-dinitroaniline 
• 125797-39-9 acetic acid-(2-anilino-5-nitro-anilide) 
• 55315-12-3 2-amino-4-nitro-N₁-phenylaniline 
• 299927-16-5 N-(2-methyl-1-phenyl-1H-benzimidazol-5-yl)-acetamide 

Downstream Products

• 33413-15-9 2-methyl-1-phenyl-5-(3-phenyl-triazenyl)-1H-benzoimidazole 
• 19593-65-8 7-methyl-6-phenyl-6H-imidazo[4',5':3,4]benzo[1,2-d]thiazol-2-ylamine 

Relevant academic research and scientific papers

Novel benzimidazole-based MCH R1 antagonists

The identification of an MCH R1 antagonist screening hit led to the optimization of a class of benzimidazole-based MCH R1 antagonists. Structure-activity relationships and efforts to optimize pharmacokinetic properties are detailed along with the demonstration of the effectiveness of an MCH R1 antagonist in an animal model of obesity.

INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 AND TYPE 2

There is provided a compound having Formula (I): wherein one of R1 and R2 is a group of the Formula (a), wherein R4 is selected from H and hydrocarbyl, R5 is a hydrocarbyl group and L is an optional linker group, or R1 and R2 together form a ring substituted with the group (Formula (a)) wherein R3 is H or a substituent, and wherein X is selected from S, O, NR6 and C(R7)(R8), wherein R6 is selected from H and hydrocarbyl groups, wherein each of R7 and R8 are independently selected from H and hydrocarbyl groups.