301835-02-9

Upstream product

• 108-43-0 3-monochlorophenol 
• 301835-01-8 Methanesulfonic acid (S)-1-(3-chloro-phenoxymethyl)-prop-2-ynyl ester 
• 86912-84-7 (+/-)-4-(3-chlorophenoxy)-1-butyne-3-ol 
• 86912-81-4 (3-chlorophenoxy)acetaldehyde diethyl acetal 
• 86912-83-6 (3-chlorophenoxy)acetaldehyde 
• 301835-00-7 (R)-4-(3-chlorophenoxy)-1-butyne-3-yl propionate 
• 4301-14-8 acetylenemagnesium bromide 

Relevant academic research and scientific papers

An Enantioconvergent Synthesis of (R)-4-Aryloxy-1-butyne-3-ols for Prostanoid Side Chains

The single enantiomer title alcohols, useful as co-side chain precursors for pharmaceutically important prostaglandin analogues were synthesised from the corresponding racemic alcohols by a convenient 4-step sequence. After enzymatic acylation of the alco

Process for the preparation of prostaglandin precursors

A propargylic alcohol, enriched in the (R)-enantiomer, has the formula wherein R is C1-4 alkoxy, halogen, or C1-4 alkyl optionally substituted by OH or halogen. This is prepared by the steps of: (a) enantioselective (R)-esterification of the racemic alcohol using any acyl donor and a first enzyme; (b) removal of the untreated (S)-alcohol; and (c) enantioselective hydrolysis of the (R)-ester, using a second enzyme.