301836-30-6

Basic information

• Product Name: Benzoic acid, 4-[4-(4-fluorophenyl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-
• CAS NO: 301836-30-6
• Molecular Formula: C21H14FN3O2
• Molecular Weight: 359.359
• Mol File: 301836-30-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[4-(4-fluorophenyl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[4-(4-fluorophenyl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-(301836-30-6)
• EPA Substance Registry System: Benzoic acid, 4-[4-(4-fluorophenyl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-(301836-30-6)

Safety Data

• Hazardous Substances Data: 301836-30-6(Hazardous Substances Data)

Upstream product

• 366-62-1 2-(4-fluoro-phenyl)-1-pyridin-2-yl-ethanone 
• 301836-29-3 4-[4-(4-fluorophenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzonitrile 
• 301836-28-2 2-(4-cyanophenyl)-4-(4-fluorophenyl)-N-1-hydroxy-5-(2-pyridyl)-imidazole 

Downstream Products

• 301836-32-8 ethyl 4-[4-(4-fluorophenyl)-5-(pyridin-2-yl)-1H-imidazol-2-yl]benzoate 
• 301836-31-7 methyl 4-[4-(4-fluorophenyl)-5-(pyridin-2-yl)-1H-imidazol-2-yl]benzoate 

Relevant articles and documents

Identification of novel inhibitors of the transforming growth factor β1 (TGF-β1) type 1 receptor (ALK5)

Screening of our internal compound collection for inhibitors of the transforming growth factor β1 (TGF-β1) type I receptor (ALK5) identified several hits. Optimization of the dihydropyrroloimidazole hit 2 by introduction of a 2-pyridine and 3,4-methylenedioxyphenyl group gave 7, a selective ALK5 inhibitor. With this information, optimization of the triarylimidazole hit 8 gave the selective inhibitor 14, which inhibits TGF-β1-induced fibronectin mRNA formation while displaying no measurable cytotoxicity in the 48 h XTT assay.