30186-38-0

Usage

Uses

Used in Pharmaceutical Production:
1-(4-METHYLPHENYL)-1H-PYRROLE-2-CARBALDEHYDE is used as a key intermediate in the synthesis of various pharmaceuticals for its unique chemical properties that contribute to the development of new drugs.
Used in Agrochemical Production:
In the agrochemical industry, 1-(4-METHYLPHENYL)-1H-PYRROLE-2-CARBALDEHYDE is utilized as a precursor in the creation of agrochemicals, leveraging its chemical characteristics to enhance crop protection and management.
Used in Organic Synthesis:
As a reagent in organic synthesis, 1-(4-METHYLPHENYL)-1H-PYRROLE-2-CARBALDEHYDE is employed for its ability to participate in various chemical reactions, facilitating the construction of complex organic molecules.
Used in Materials Science:
In the field of materials science, 1-(4-METHYLPHENYL)-1H-PYRROLE-2-CARBALDEHYDE is used as a component in the development of new materials, potentially contributing to advancements in material properties and applications.

InChI:InChI=1/C12H11NO/c1-10-4-6-11(7-5-10)13-8-2-3-12(13)9-14/h2-9H,1H3

Upstream product

• 98-01-1 furfural 
• 106-49-0 p-toluidine 
• 827-60-1 1-(4-methylphenyl)-1H-pyrrole 
• 68-12-2 N,N-dimethyl-formamide 
• 109-97-7 pyrrole 

Downstream Products

• 35524-48-2 1-(4-methylphenyl)pyrrole-2-carbonitrile 
• 144062-81-7 1-<4-<(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl>phenyl>-5-(trifluoromethyl)-1H-pyrrole-2-carbonitrile 
• 145355-18-6 1-<4-<(2-n-butyl-4,5-dicarbamoyl-1H-imidazol-1-yl)methyl>phenyl>-1H-pyrrole-2-carbonitrile 
• 1410884-81-9 (E)-N-(tert-butyl)-4-ethylidene-6-(4-methoxybenzyl)-5-oxo-1-(ptolyl)-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-7-carboxamide 
• 1410885-01-6 N-(tert-butyl)-7-(4-methoxybenzyl)-4-methyl-6-oxo-1-(p-tolyl)-1,6,7,8-tetrahydropyrrolo[2,3-c]azepine-8-carboxamide 
• 1410884-63-7 N-(2-(tert-butylamino)-2-oxo-1-(1-(p-tolyl)-1H-pyrrol-2-yl)ethyl)-N-(4-methoxybenzyl)but-2-ynamide 
• 145062-01-7 methyl 1-<4-<<2-n-butyl-4-chloro-5-(hydroxymethyl)imidazolyl>methyl>phenyl>-1H-pyrrole-2-carboxylate 
• 145355-20-0 1-[4-(3,5-Dibutyl-[1,2,4]triazol-1-ylmethyl)-phenyl]-4-nitro-1H-pyrrole-2-carbonitrile 
• 144062-77-1 1-<4-<(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl>phenyl>-3,5-dichloro-1H-pyrrole-2-carbonitrile 
• 144062-65-7 1-<4-<(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl>phenyl>-1H-pyrrole-2-carbonitrile 
• 145355-19-7 1-<4-<(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl>phenyl>-5-fluoro-1H-pyrrole-2-carbonitrile 
• 145062-02-8 methyl 1-<4-<<2-n-butyl-4-(hydroxymethyl)-5-chloroimidazolyl>methyl>phenyl>-1H-pyrrole-2-carboxylate 
• 144062-64-6 methyl 1-<4-<(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl>phenyl>-1H-pyrrole-2-carboxylate 

Relevant academic research and scientific papers

Rearrangement and cyclisation reactions on the 1-Arylpyrrol-2-iminyl-2-Aryliminopyrrol-1-yl radical energy surface

Independent generation of the iminyl (X = N) and pyrrol-1-yl (X = N) radicals by flash vacuum pyrolysis of the corresponding oxime ether and N-(dimethylamino) compound, respectively, provides two regioisomeric pyrrolo1,2-A]quinoxalines compounds. This shows that the radical species interconvert via the spirodienyl moeity at high temperatures. Corresponding generation of the pyrrol-1-yl (X = CH) radical gives the pyrrolo[1,2-A]quinoline as the only cyclised product. In this case, DFT calculations suggest that direct cyclisation of the pyrrol-1-yl takes place, rather than formation of the spirodienyl species and exclusive migration of the C-N bond.

Selective and Efficient Formylation of Indoles (C3) and Pyrroles (C2) Using 2,4,6-Trichloro-1,3,5-Triazine/Dimethylformamide (TCT/DMF) Mixed Reagent

This study introduces an efficient method for the selective formylation of indoles and pyrroles at the positions of C(3) and C(2), respectively. The mixture of three equivalents of N,N-dimethylformamide and one equivalent of 2,4,6-trichloro-1,3,5-triazine (cyanuric chloride) generates an easy handling formylating agent for the efficient formylation of these classes of compounds to give the corresponding aldehydes under mild reaction conditions. This procedure was highly efficient, and a range of formylated indoles and pyrroles were obtained in good to excellent yields.

N-SUBSTITUTED (ALPHA-IMIDAZOLYL-TOLUYL) PYRROLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS

A class of N-substituted (α-imidazolyl-toluyl)pyrrole compounds described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula STR1 wherein m is one; wherein each of R 0 and R 1 is i

Nonpeptide angiotensin II antagonists: N-phenyl-1H-pyrrole derivatives are angiotensin II receptor antagonists

A series of 5-[1-[4-[(4,5-disubstituted-1H-imidazol-1-yl)methyl]- substituted]-1H-pyrrol-2-yl]-1H-tetrazoles and 5-[1-[4-[(3,5-dibutyl-1H- 1,2,4-triazol-1-yl)methyl]-substituted]-1H-pyrrol-2-yl]-1H-tetrazoles were investigated as novel AT1-sele

N-SUBSTITUTED N-(ALPHA-TRIAZOLYL-TOLUYL)PYRROLE COMPOUNDS AND USE FOR TREATMENT OF CIRCULATORY DISORDERS

A class of N-substituted N-(α-triazolyltoluyl)pyrrole compounds described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula STR1 wherein m is one; wherein R 1 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, 4-methylbutyl, n-pentyl, neopentyl, phenyl, benzyl, phenethyl, cyclohexyl, cyclohexylmethyl, cyclohexylethyl, cyclohexanoyl, 1-oxo-2-cyclohexylethyl, benzoyl, 1-oxo-2-phenethyl, 1-oxopropyl, 1-oxobutyl, 1-oxopentyl and 2-hydroxybutyl; wherein R 2 is selected from methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, isopentyl, neopentyl, phenyl, benzyl, phenethyl, cyclohexyl, cyclohexylmethyl, propylthio, butylthio, and hydroxyalkyl; wherein each of R 3, R 4, R 5, R 6, R 7, R 8, R 9 and R. sup.10 is independently selected from hydrido, halo, nitro, trifluoromethyl, hydroxy, alkoxy, cyano, carboxyl and methoxycarbonyl; with the proviso that at least one of R 5 and R 8 must be selected from COOH, SH, PO 3 H 2, SO 3 H, CONHNH 2, CONHNHSO 2 CF 3, OH, STR2 wherein each of R 42 and R 43 is independently selected from chloro, cyano, nitro, trifluoromethyl, methoxycarbonyl and trifluoromethylsulfonyl; or a tautomer thereof or a pharmaceutically-acceptable salt thereof. These compounds are particularly useful in treatment or control of hypertension and congestive heart failure.

SYNTHESIS AND SPECTRAL PROPERTIES OF 1-ARYL-2-FORMYLPYRROLES

Various 1-aryl-2-formylpyrroles were synthesized by reaction of furfurol with substituted anilines.For p-bromo- and p-chlorophenyl substituents, the intermediate Schiff bases were isolated.

Reactions of Stenhouse Salts. III Transformation Products Under Acidic and Basic Conditions

Mild acid treatment of alcoholic solutions of Stenhouse salts has been shown to yield a mixture of the corresponding N-arylpyrrole-2-carbaldehyde and the N-aryl-3-hydroxypyridinium salt.Treatment of alcoholic solutions of the Stenhouse salts with a variety of bases leads to 4-substituted 2-arylaminocyclopent-2-enones.