302-33-0 Usage
Uses
Synergist (non-specific).
Enzyme inhibitor
This nonselective P450 inhibitor (FWfree-base = 353.50 g/mol; CAS 302-33-0;
62-68-0 for the HCl salt), also known as SKF-525A, b-diethylaminoethyl
2,2-diphenylpropylacetate, and N,N-diethylaminoethyl 2,2-
diphenylvalerate, blocks glibenclamide-sensitive K+ channels, including
ATP-sensitive inward rectifier potassium channel 8 (KIR6.1). As a
nonselective inhibitor of cytochrome P450 systems, proadifen also inhibits
drug metabolism, thereby potentiating the action of many pharmaceuticals.
For example, proadifen inhibits the demethylation of 2-methoxyestrogens
. Target (s) : aldehyde oxidase; alkanal monooxygenase, FMN-
linked; aromatase, or CYP19; bacterial luciferase, or alkanal
monooxygenase, FMN-linked; benzoate 4-monooxygenase;
bromomethane monooxygenase7; calcium influx8; ent-copalyl-diphosphate
synthase; CYPC211; cytochrome P450; diamine N-
acetyltransferase; N,N-dimethylaniline demethylase; ecdysone 20-
monooxygenase; ethoxyresorufin O-deethylase; flavin-containing
monooxygenase, or dimethylaniline-N-oxide aldolase; glyceollin
synthase; 2-hydroxyisoflavanone synthase; 25-hydroxyvitamin D3
24-monooxygenase; isopentenyl-diphosphate D-isomerase, or
isopentenyl-pyrophosphate D-isomerase; ent-kaurene synthase;
leukotriene B4 20-hydroxylase; (S) -limonene 3-monooxygenase;
(S) -limonene 6-monooxygenase; (S) -limonene 7-monooxygenase;
methane monooxygenase; monoamine oxidase;
NADPH:cytochrome P450 reductase; nitric-oxide synthase, neuronal
; pentoxyresorufin O-depentylase; phenol O-methyltransferase
; progesterone 11a-monooxygenase; steroid 11b-monooxygenase
; steroid 21-monooxygenase, or CYP21A1, weakly inhibited;
sterol 14-demethylase, or CYP51; styrene monooxygenase; thiol
S-methyltransferase; thromboxane production; and
trimethylamine-oxide aldolase.
Check Digit Verification of cas no
The CAS Registry Mumber 302-33-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,0 and 2 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 302-33:
(5*3)+(4*0)+(3*2)+(2*3)+(1*3)=30
30 % 10 = 0
So 302-33-0 is a valid CAS Registry Number.
InChI:InChI=1/C23H31NO2/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3/h7-16H,4-6,17-19H2,1-3H3
302-33-0Relevant articles and documents
Molecular Modification of Anticholinergics as Probes for Muscarinic Receptors. Amino Esters of α-Substituted Phenylacetic Acid and Related Analogues
Lu, Mattias C.,Wung, Walley E.,Shih, Lisa B.,Callejas, Soledad,Gearien, James E.,Thompson, Emmanuel B.
, p. 273 - 278 (2007/10/02)
Two series of compounds having the general structure of C6H5CRR'COOCH2CH2NEt2 were synthesized and examined for their antispasmodic activities.These compounds were selected as structural probes for exploring the nature of muscarinic cholinergic receptor binding sites that interact with atropine-like anticholinergics.These studies indicate a rather strict size limitation for the hydrophobic region of the receptor and suggest intramolecular hydrogen bonding as a possible means to explain the observed stereoselectivity.