30219-13-7

Basic information

• Product Name: Bufalin-3-hydrogen suberate
• Synonyms: Bufalin-3-hydrogen suberate;3-(Hydrogen suberoyl)bufalin;3β-(7-Carboxy-1-oxoheptyloxy)-14β-hydroxy-5β-bufa-20,22-dienolide;3β-(7-Carboxyheptanoyloxy)-14-hydroxy-5β-bufa-20,22-dienolide
• CAS NO: 30219-13-7
• Molecular Formula: C₃₂H₄₆O₇
• Molecular Weight: 542.70344
• Mol File: 30219-13-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Bufalin-3-hydrogen suberate(CAS DataBase Reference)
• NIST Chemistry Reference: Bufalin-3-hydrogen suberate(30219-13-7)
• EPA Substance Registry System: Bufalin-3-hydrogen suberate(30219-13-7)

Safety Data

• Hazardous Substances Data: 30219-13-7(Hazardous Substances Data)

Upstream product

• 10521-06-9 oxonane-2,9-dione 
• 465-21-4 5-((3S,5R,8R,9S,10S,13R,14S)-3,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one 

Relevant articles and documents

Synthesis of Bufalitoxin and Bufotoxin

Completion of a formal total synthetic route to the toad venom constituents bufotalin (8), cinobufagin (2a), bufalitoxin (3f), and bufotoxin (1a) has been accomplished.Bufalin (3a) was employed as relay and converted to 14-dehydrobufalin 3-acetate (4).Selective oxidation of olefin 4 with a chromium trioxide-pyridine reagent afforded 16-ketone 5, which we had previously transformed to bufotalin (8) and thence to cinobufagin (2a).Condensation of bufalin (3a) with suberic anhydride followed by a mixed carbonic anhydride reaction sequence using arginine monohydrochloride yielded bufalitoxin (3f), and an analogous route from bufotalin (8) led to bufotoxin (1a).