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1,3-Dihydro-5-(2-chlorophenyl)-2H-1,4-benzodiozepin-2-one, commonly known as clonazepam, is a benzodiazepine medication that plays a crucial role in the management of neurological conditions such as seizures, panic disorder, and anxiety. It functions by augmenting the effects of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain, which aids in calming the nerves and reducing excessive electrical activity. Clonazepam is available in both brand-name and generic forms and is typically administered orally in the form of a tablet or disintegrating tablet. It is essential to follow the prescription guidelines provided by a healthcare professional to avoid the risks of dependence, addiction, and severe withdrawal symptoms. The medication may cause common side effects such as drowsiness, dizziness, and coordination problems.

3022-68-2

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3022-68-2 Usage

Uses

Used in Pharmaceutical Industry:
1,3-Dihydro-5-(2-chlorophenyl)-2H-1,4-benzodiozepin-2-one is used as a therapeutic agent for the treatment of neurological disorders such as seizures, panic disorder, and anxiety. It is utilized for its ability to enhance the effects of gamma-aminobutyric acid (GABA) in the brain, which helps to calm the nerves and reduce excessive electrical activity, providing relief from the symptoms associated with these conditions.
Used in Medical Treatments:
1,3-Dihydro-5-(2-chlorophenyl)-2H-1,4-benzodiozepin-2-one is used as a medication to manage the symptoms of neurological conditions, providing a calming effect on the nerves and reducing the excessive electrical activity in the brain. This helps in alleviating the distress caused by seizures, panic disorder, and anxiety, improving the quality of life for patients suffering from these conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 3022-68-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,0,2 and 2 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 3022-68:
(6*3)+(5*0)+(4*2)+(3*2)+(2*6)+(1*8)=52
52 % 10 = 2
So 3022-68-2 is a valid CAS Registry Number.

3022-68-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,3-Dihydro-5-(2-chlorophenyl)-2H-1,4-benzodiozepin-2-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3022-68-2 SDS

3022-68-2Synthetic route

Ethyl isocyanoacetate
2999-46-4

Ethyl isocyanoacetate

5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
3022-68-2

5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

6-(2-Chloro-phenyl)-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid ethyl ester
98601-26-4

6-(2-Chloro-phenyl)-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multistep reaction;
3-(isocyanomethyl)-5-methyl-1,2,4-oxadiazole
110035-82-0

3-(isocyanomethyl)-5-methyl-1,2,4-oxadiazole

5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
3022-68-2

5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

6-(2-Chloro-phenyl)-3-(5-methyl-[1,2,4]oxadiazol-3-yl)-4H-2,5,10b-triaza-benzo[e]azulene

6-(2-Chloro-phenyl)-3-(5-methyl-[1,2,4]oxadiazol-3-yl)-4H-2,5,10b-triaza-benzo[e]azulene

Conditions
ConditionsYield
Yield given. Multistep reaction;
5-Ethyl-3-isocyanomethyl-1,2,4-oxadiazole
110035-81-9

5-Ethyl-3-isocyanomethyl-1,2,4-oxadiazole

5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
3022-68-2

5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

6-(2-Chloro-phenyl)-3-(5-ethyl-[1,2,4]oxadiazol-3-yl)-4H-2,5,10b-triaza-benzo[e]azulene

6-(2-Chloro-phenyl)-3-(5-ethyl-[1,2,4]oxadiazol-3-yl)-4H-2,5,10b-triaza-benzo[e]azulene

Conditions
ConditionsYield
Yield given. Multistep reaction;
3-(isocyanomethyl)-5-isopropyl-1,2,4-oxadiazole
122384-66-1

3-(isocyanomethyl)-5-isopropyl-1,2,4-oxadiazole

5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
3022-68-2

5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

6-(2-Chloro-phenyl)-3-(5-isopropyl-[1,2,4]oxadiazol-3-yl)-4H-2,5,10b-triaza-benzo[e]azulene

6-(2-Chloro-phenyl)-3-(5-isopropyl-[1,2,4]oxadiazol-3-yl)-4H-2,5,10b-triaza-benzo[e]azulene

Conditions
ConditionsYield
Yield given. Multistep reaction;
3-(isocyanomethyl)-5-n-propyl-1,2,4-oxadiazole
122384-67-2

3-(isocyanomethyl)-5-n-propyl-1,2,4-oxadiazole

5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
3022-68-2

5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

6-(2-Chloro-phenyl)-3-(5-propyl-[1,2,4]oxadiazol-3-yl)-4H-2,5,10b-triaza-benzo[e]azulene

6-(2-Chloro-phenyl)-3-(5-propyl-[1,2,4]oxadiazol-3-yl)-4H-2,5,10b-triaza-benzo[e]azulene

Conditions
ConditionsYield
Yield given. Multistep reaction;
5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
3022-68-2

5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

6-(2-Chloro-phenyl)-3-(3-methyl-[1,2,4]oxadiazol-5-yl)-4H-2,5,10b-triaza-benzo[e]azulene

6-(2-Chloro-phenyl)-3-(3-methyl-[1,2,4]oxadiazol-5-yl)-4H-2,5,10b-triaza-benzo[e]azulene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: 1) NaH, molecular sieves / 1) THF, r.t., 2) THF, reflux
View Scheme
5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
3022-68-2

5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

6-(2-Chloro-phenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-4H-2,5,10b-triaza-benzo[e]azulene

6-(2-Chloro-phenyl)-3-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-4H-2,5,10b-triaza-benzo[e]azulene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: 1) NaH, molecular sieves / 1) THF, r.t., 2) THF, reflux
View Scheme
bromoacetic acid methyl ester
96-32-2

bromoacetic acid methyl ester

5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
3022-68-2

5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

[5-(2-chloro-phenyl)-2-oxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid methyl ester
49613-98-1

[5-(2-chloro-phenyl)-2-oxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid methyl ester

Conditions
ConditionsYield
With sodium methylate In N-methyl-acetamide; water; toluene
5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
3022-68-2

5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepine-2-thione
39061-98-8

5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepine-2-thione

Conditions
ConditionsYield
With Lawessons reagent In 1,2-dimethoxyethane at 75℃;
5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
3022-68-2

5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

[5-(2-chloro-phenyl)-2-thioxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid methyl ester
49614-05-3

[5-(2-chloro-phenyl)-2-thioxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium methylate / N-methyl-acetamide; water; toluene
2: pyridine; diphosphorus pentasulfide / methylene chloride-water; dichloromethane
View Scheme

3022-68-2Upstream product

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