30223-73-5Relevant articles and documents
An in vitro approach to potential methadone metabolic-inhibition interactions
Bomsien, Stephanie,Skopp, Gisela
, p. 821 - 827 (2007)
Objective: The aim of this study was to assess the drug interaction potential of psychotropic medication on methadone N-demethylation using cDNA-expressed cytochrome P450 CYP enzymes. Methods: Methadone was incubated with various drugs (n = 10) and cDNA-e
Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes
Iribarne, Christelle,Berthou, Francois,Baird, Susan,Dreano, Yvonne,Picart, Daniel,Bail, Jean Pierre,Beaune, Philippe,Menez, Jean Francois
, p. 365 - 373 (1996)
Methadone has become one of the most widely used drugs for opiate dependency treatment. This drug is extensively metabolized by the cytochrome P450 hepatic enzyme family in man, yielding an N-demethylated metabolite that cyclizes spontaneously into 2-ethy