30236-02-3

Usage

Uses

Used in Organic Synthesis:
4-(Bromomethyl)naphthalene-1-carboxylic acid is used as a key intermediate in organic synthesis for the production of a wide range of chemical compounds. Its presence of both a carboxylic acid and a bromomethyl group makes it a valuable building block for the synthesis of various organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-(Bromomethyl)naphthalene-1-carboxylic acid is used as a precursor for the synthesis of pharmacologically active compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
4-(Bromomethyl)naphthalene-1-carboxylic acid is also utilized in the agrochemical industry as a starting material for the synthesis of various agrochemicals, including pesticides and herbicides, due to its potential to be incorporated into molecules with biocidal properties.
Used as a Reagent for Functionalized Naphthalene Derivatives:
4-(BROMOMETHYL)NAPHTHALENE-1-CARBOXYLIC ACID serves as a reagent for the preparation of a variety of functionalized naphthalene derivatives, which are important in various chemical and material science applications.
Used in Anti-Cancer Research:
4-(Bromomethyl)naphthalene-1-carboxylic acid is studied for its potential as an anti-cancer agent, with ongoing research exploring its effects on different types of cancer cells and its possible integration into cancer treatment strategies.
Used in Antimicrobial Applications:
Due to its antimicrobial properties, 4-(Bromomethyl)naphthalene-1-carboxylic acid is being investigated for use in applications where control of microbial growth is necessary, such as in medical settings or in the development of antimicrobial coatings and materials.

Upstream product

• 79996-84-2 4-methoxymethyl-1-naphthoic acid 
• 4488-40-8 4-Methyl-1-naphthoic acid 
• 28418-86-2 1-acetyl-4-methylnaphthalene 
• 90-12-0 1-Methylnaphthalene 
• 79996-80-8 1-acetyl-4-bromomethylnaphthalene 
• 79996-79-5 1-acetyl-4-methoxymethylnaphthalene 

Downstream Products

• 219685-15-1 4-formylnaphthalene-1-carboxylic acid 
• 2417-75-6 methyl 4-bromomethylnaphthalene-1-carboxylate 

Relevant academic research and scientific papers

Method for preparing oxazoline insecticide arforaging intermediate

The invention discloses a method for preparing an oxazoline insecticide arfamarin intermediate. The intermediate is 4-formyl-naphthalene-1-carboxylic acid, and compared with a synthesis route of US6613942B1, the synthesis route of the oxazoline insecticide arfamarin is simple. According to the method provided by some embodiments of the invention, through exploration, the reaction steps are shortened from three steps to one step, so the oxazoline insecticide arforlaana intermediate product with qualified purity can be obtained. The intermediate control steps are simplified, meanwhile, the product yield is increased, and industrial production is easier.

Pd-catalyzed allylative dearomatisation using Grignard reagents

Pd-catalyzed allylative dearomatisation of naphthyl halides is shown to be feasible by employing Grignard reagents. The high reactivity of the nucleophile allows for fast reactions and low catalyst loading, while a plethora of successfully substituted compounds illustrate the broad scope. Five membered heteroaromatic compounds are also demonstrated to be reactive under similar conditions.

INSECTICIDAL ARYLPYRROLINES

The invention relates to novel arylpyrroline compounds of formula (I) which have excellent insecticidal activity and which can thus be used as insecticides.

ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER

Compounds of formula I or pharmaceutically acceptable salts thereof: [Chemical formula should be inserted here. Please see paper copy] I wherein X, R1, R2, R3, m and n are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Glucagon antagonists/inverse agonists

Non-peptide compounds comprising a central hydrazide motif and methods for the synthesis thereof are disclosed. The compounds act to antagonize the action of the glucagon peptide hormone.

Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6-tetramethylbenzyl)-1h-indol-4ylmethylene]hydrazide

Highly potent human glucagon receptor (hGluR) antagonists have been prepared employing both medicinal chemistry and targeted libraries based on modification of the core (proximal) dimethoxyphenyl group, the benzyl ether linkage, as well as the (distal) benzylic aryl group of the lead 2, 3-cyano-4-hydroxybenzoic acid (3,5-dimethoxy-4-isopropylbenzyloxybenzylidene)hydrazide. Electron-rich proximal aryl moieties such as mono- and dimethoxy benzenes, naphthalenes, and indoles were found to be active. The SAR was found to be quite insensitive regarding the linkage to the distal aryl group, since long and short as well as polar and apolar linkers gave highly potent compounds. The presence of a distal aryl group was not crucial for obtaining high binding affinity to the hGluR. In many cases, however, the affinity could be further optimized with substituted distal aryl groups. Representative compounds have been tested for in vitro metabolism, and structure - metabolism relationships are described. These efforts lead to the discovery of 74, NNC 25-2504, 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide, with low in vitro metabolic turnover. 74 was a highly potent noncompetitive antagonist of the human glucagon receptor (IC50 = 2.3 nM, KB = 760 pM) and of the isolated rat receptor (IC50 = 430 pM, KB = 380 pM). Glucagonstimulated glucose production from isolated primary rat hepatocytes was inhibited competitively by 74 (Ki = 14 nM). This compound was orally available in dogs (Fpo = 15%) and was active in a glucagon-challenged rat model of hyperglucagonemia and hyperglycemia.

Preparation of a series of substituted fluoromethylnaphthalenes

A series of 22 3- and 4-substituted 1-fluoromethylnaphthalenes have been synthesized.Details of practical procedures for the preparation of all intermediates are described, and physical properties for all of the substituted naphthalenes synthesized, and spectral parameters for 51 previously unknown compounds, are given.