3026-54-8Relevant academic research and scientific papers
5-[3-[PIPERAZIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS
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Paragraph 0219; 0304, (2018/01/15)
The present invention discloses 5-[3-[piperazin-l-yl]-3-oxo-propyl]-imidazolidine-2,4-dione derivatives according to Formula (I), wherein R1, R2, R3a, R3b, R6a, R6b, the subscript n and Cy are as defined herein. The present invention relates to compounds inhibiting ADAMTS 4 and 5 for the prophylaxis or treatment of inflammatory diseases or diseases involving degradation of cartilage or disruption of cartilage homeostasis, such as e.g. osteoarthritis.
Practical method for parallel synthesis of diversely substituted 1-phenylpiperazines
Konstantinova, Igor,Bukhryakov, Konstantin,Gezentsvey, Yuri,Krasavin, Mikhail
experimental part, p. 628 - 630 (2012/05/21)
A simple and practical method to prepare 'libraries' of substituted 1-phenylpiperazine building blocks in parallel format has been developed.
Arylpiperazine-benzoylamide derivatives useful as pharmaceutical agents
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Page/Page column 8, (2010/11/08)
The invention relates to arylpiperazine-benzoylamide derivatives of formula (I) wherein A, X1, X2, n and R1 to R10 are defined as in claim 1, which are suitable for the treatment of diseases characterized by exc
PIPERAZINE OXYTOCIN RECEPTOR ANTAGONISTS
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, (2008/06/13)
This invention relates to certain novel piperazine compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.
