30278-80-9Relevant academic research and scientific papers
Synthesis and biological screening of some new 1,5-benzodiazepine derivatives as promising antibacterial and antitubercular agents
Monga, Vikramdeep,Nayak, Surendra Kumar,Singh, Gurpreet
, p. 143 - 149 (2020/07/21)
In this study, various substituted 1,5-benzodiazepines were synthesized by condensing different substituted chalcones with o-phenylenediamine in methanol using piperidine as a base under refluxing conditions and were obtained in good yield after purificat
Dual inhibition of the α-glucosidase and butyrylcholinesterase studied by Molecular Field Topology Analysis
Jabeen, Farukh,Oliferenko, Polina V.,Oliferenko, Alexander A.,Pillai, Girinath G.,Ansari, Farzana Latif,Hall, C. Dennis,Katritzky, Alan R.
, p. 228 - 242 (2014/05/20)
A striking dual inhibition of enzymes α-glucosidase and butyrylcholinesterase by small drug-like molecules, including 1,4-disubstituted-1,2,3-triazoles, chalcones, and benzothiazepines, was rationalized with the help of Molecular Field Topology Analysis, a 3D QSAR technique similar to CoMFA. A common pharmacophore supported the concept of a link existing between type-2 diabetes mellitus and Alzheimer's disease. These findings will be instrumental for rational design of drug candidates for both of these conditions.
Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors
Sonmez, Fatih,Sevmezler, Sedat,Atahan, Alparslan,Ceylan, Mustafa,Demir, Dudu,Gencer, Nahit,Arslan, Oktay,Kucukislamoglu, Mustafa
, p. 7479 - 7482 (2012/02/04)
A newly series of 4-(phenylurenyl)chalcone (4a-j) and 4′- (phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-l-tyrosine-p-aminobenzoic acid. The result showed that 4a-j inhibited the PPO enzyme activity. Conversely, 9a-h and 9i-l showed activator effect on tyrosinase enzyme activity.
PERCHLORIC ACID-ACETIC ACID: A REAGENT SYSTEM FOR DETOSYLATION
Kudav, D.P.,Samant,S.P.,Hosangadi, B.D.
, p. 1185 - 1188 (2007/10/02)
Perchloric acid-acetic acid reagent system has been found to be an efficient reagent for deprotection of p-methyl benzene sulfonyl (tosyl) derivatives of primary aromatic amines, secondary aromatic amines and chiral aminoketones.
