30278-84-3Relevant academic research and scientific papers
Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors
Sonmez, Fatih,Sevmezler, Sedat,Atahan, Alparslan,Ceylan, Mustafa,Demir, Dudu,Gencer, Nahit,Arslan, Oktay,Kucukislamoglu, Mustafa
, p. 7479 - 7482 (2012/02/04)
A newly series of 4-(phenylurenyl)chalcone (4a-j) and 4′- (phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-l-tyrosine-p-aminobenzoic acid. The result showed that 4a-j inhibited the PPO enzyme activity. Conversely, 9a-h and 9i-l showed activator effect on tyrosinase enzyme activity.
