302802-16-0Relevant academic research and scientific papers
Synthesis and anti-inflammatory activities of 4H-chromene and chromeno[2,3-b]pyridine derivatives
Chung, Shu-Ting,Huang, Wen-Hsin,Huang, Chih-Kuo,Liu, Feng-Cheng,Huang, Ren-Yeong,Wu, Chin-Chen,Lee, An-Rong
, p. 1195 - 1215 (2016)
Several derivatives of 4H-chromene and chromeno[2,3-b]pyridine were efficiently prepared under microwave irradiation in a one-pot reaction, and their anti-inflammatory activities were evaluated. Six synthetic products (1b, 1c, 1h, 2d, 2j, and 2l) exhibited more powerfully inhibited the production of tumor necrosis factor-α-induced nitric oxide (NO) than quercetin and exhibited comparable cell viability in both human and porcine chondrocytes. In particular, 2d at dosages of 10 and 20 mg/kg had a very potent anti-inflammatory effect by suppressing the formation of carrageenan-induced rat paw edema and prostaglandin E2. The results herein suggest that these compounds may have potential as structural templates in the design and development of new anti-inflammatory drugs.
Polyalkoxy substituted 4H-chromenes: Synthesis by domino reaction and anticancer activity
Shestopalov, Anatoliy M.,Litvinov, Yuri M.,Rodinovskaya, Lyudmila A.,Malyshev, Oleg R.,Semenova, Marina N.,Semenov, Victor V.
, p. 484 - 490 (2012/11/07)
A series of 4H-chromenes containing various modifications in the ring B and polyalkoxy substituents in the ring E has been synthesized by Knoevenagel-Michael-hetero-Thorpe-Ziegler three-component domino reaction with the overall yield of 45-82%. The targe
Substituted 4H-chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
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, (2008/06/13)
The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the general Formula I: 1wherein R1-R5, A, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
