302838-69-3

Upstream product

• 1003-03-8 Cyclopentamine 
• 302839-27-6 4-[4-bromo-2-(3-trifluoromethyl-phenyl)-imidazol-1-yl]-2-methanesulfinyl-pyrimidine 
• 302839-26-5 4-[4-bromo-2-(3-trifluoromethyl-phenyl)-imidazol-1-yl]-2-methylsulfanyl-pyrimidine 

Relevant academic research and scientific papers

Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis

A library of trisubstituted oxazoles, thiazoles, imidazoles (1,2,4- and 2,4,5-substituted) and imidazo[1,2-b]pyridines was prepared and evaluated in vitro as p38α inhibitors and in vivo in several models of rheumatoid arthritis. Four structures - 32, 37,

Substituted azoles

wherein the symbols have meaning as defined herein, are p38 MAP kinase inhibitors, and are useful pharmaceutically for treating TNFα and IL-1 mediated diseases, such as rheumatoid arthritis, and diseases of bone metabolism, e.g. osteoporosis.