302840-50-2

Upstream product

• 302840-48-8 methyl 2-[(1R,2R)-2-(tert-butyldimethylsilyloxy)-1,5,5-trimethyl-6-methylenecyclohexyl]acetate 
• 302840-49-9 (1R,2R)-2-[2-(tert-butyldimethylsilyloxy)-1,5,5-trimethyl-6-methylenecyclohexyl]acetic acid 
• 302840-45-5 ((1R,6R)-6-Hydroxy-1,3,3-trimethyl-2-methylene-cyclohexyl)-acetic acid 
• 302840-44-4 (1R)-1,5,5-trimethyl-6-methylene-2-oxocyclohexylacetic acid 
• 302840-46-6 methyl 2-[(1R,2R)-2-hydroxy-1,5,5-trimethyl-6-methylenecyclohexyl]acetate 
• 302840-42-2 (+)-methyl (1R)-1,5,5-trimethyl-6-methylenecyclohexan-2-one-1-acetate 
• 302840-41-1 (+)-methyl (1R)-1,5,5-trimethyl-6-methylenecyclohex-3-en-2-one-1-acetate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 1117-96-0 Diazoethan 

Relevant academic research and scientific papers

Enantiospecific synthesis of thaps-8-en-5-ol via stereospecific intramolecular chirality transfer

Enantiospecific synthesis of thaps-8-en-5-ol, comprising of the carbon framework of a small group of sesquiterpenes containing three contiguous quaternary carbon atoms has been described. (R)-Carvone has been employed as the chiral starting material and a combination of intramolecular alkyation and Criegee fragmentation have been employed for intramolecular stereospecific transfer of the chirality. An intramolecular diazoketone cyclopropanation and regioselective cyclopropane ring cleavage reactions have been employed for the creation of the three requisite contiguous quaternary carbon atoms.

An enantiospecific approach to thapsanes from R-carvone: Synthesis of (-)-thaps-8-en-5-ol

The first enantiospecific synthesis of a thapsane, containing three contiguous quaternary carbon atoms, is accomplished starting from R-carvone. An intramolecular alkylation and an intramolecular diazoketone cyclopropanation reaction were employed for the