302841-84-5

Usage

General Description

4-[2-(1H-IMIDAZOL-4-YL)-ETHYL]-PIPERIDINE is a chemical compound with a piperidine core and an imidazole functional group attached. It is commonly used as a building block in organic synthesis, and can be found in various pharmaceutical and industrial applications. The imidazole group provides the compound with potential biological activity, as imidazole derivatives have been shown to possess a wide range of pharmacological properties. Additionally, the piperidine core is a common structural motif in many drugs and natural products, making 4-[2-(1H-IMIDAZOL-4-YL)-ETHYL]-PIPERIDINE an important intermediate for the synthesis of pharmacologically active compounds.

Upstream product

• 469863-99-8 4-[2-(imidazol-4-yl)ethyl]pyridine 
• 639089-23-9 1-benzyl-4-{2-[4-(toluene-4-sulfonyl)-4,5-dihydro-oxazol-5-yl]-ethyl}-piperidine 
• 124438-29-5 3-(1-Benzyl-piperidin-4-yl)-propan-1-ol 
• 120014-31-5 3-(1-benzylpiperidin-4-yl)propanal 
• 699021-11-9 4-{2-[4-(4-methylbenzenesulfonyl)-4,5-dihydrooxazol-5-yl]ethyl}pyridine 
• 120690-80-4 3-(pyridin-4-yl)propionaldehyde 
• 2629-72-3 4-(3-Hydroxypropyl)pyridine 
• 639089-26-2 1-benzyl-4-[2-(3H-imidazol-4-yl)-ethyl]-piperidine 

Relevant academic research and scientific papers

N-substituted piperidinyl alkyl imidazoles: Discovery of methimepip as a potent and selective histamine H3 receptor agonist

In this study, we continue our efforts toward the development of potent and highly selective histamine H3 receptor agonists. We introduced various alkyl or aryl alkyl groups on the piperidine nitrogen of the known H3/H4 agonist immepip and its analogues (1-3a). We observed that N-methyl-substituted immepip (methimepip) exhibits high affinity and agonist activity at the human histamine H3 receptor (pK i = 9.0 and pEC50 = 9.5) with a 2000-fold selectivity at the human H3 receptor over the human H4 receptor and more than a 10000-fold selectivity over the human histamine H1 and H 2 receptors. Methimepip was also very effective as an H3 receptor agonist at the guinea pig ileum (pD2 = 8.26). Moreover, in vivo microdialysis (in rat brain) showed that methimepip reduces the basal level of brain histamine to about 25% after a 5 mg/kg intraperitoneal administration.

Synthesis and Structure-Activity Relationships of Conformationally Constrained Histamine H3 Receptor Agonists

Immepip, a conformationally constrained analogue of the histamine congener imbutamine, shows high affinity and functional activity on the human H 3 receptor. Using histamine and its homologues as prototypes, other rigid analogues containing eit