302912-33-0

Basic information

• Product Name: 4-BROMO-1-ETHYNYL-2-FLUOROBENZENE 96
• Synonyms: 4-BROMO-1-ETHYNYL-2-FLUORO-BENZENE;4-BROMO-1-ETHYNYL-2-FLUOROBENZENE 96;4-BROMO-1-ETHYNYL-2-FLUOROBENZENE 96%;Benzene, 4-broMo-1-ethynyl-2-fluoro-;4-Bromo-2-fluorophenylacetylene
• CAS NO: 302912-33-0
• Molecular Formula: C₈H₄BrF
• Molecular Weight: 199.0197632
• Mol File: 302912-33-0.mol

Chemical Properties

• Melting Point: 54-59 °C(lit.)
• Boiling Point: 197.2°C at 760 mmHg
• Flash Point: 110 °C
• Appearance: /
• Density: 1.58g/cm³
• Vapor Pressure: 0.538mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-BROMO-1-ETHYNYL-2-FLUOROBENZENE 96(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-1-ETHYNYL-2-FLUOROBENZENE 96(302912-33-0)
• EPA Substance Registry System: 4-BROMO-1-ETHYNYL-2-FLUOROBENZENE 96(302912-33-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 302912-33-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-BROMO-1-ETHYNYL-2-FLUOROBENZENE 96 is used as a key intermediate in the synthesis of biologically active compounds for pharmaceutical applications. Its unique structure allows for the development of new drugs with potential therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical industry, 4-BROMO-1-ETHYNYL-2-FLUOROBENZENE 96 serves as a building block for the creation of agrochemicals, such as pesticides and herbicides, that help protect crops from pests and diseases.
Used in Organic Synthesis:
4-BROMO-1-ETHYNYL-2-FLUOROBENZENE 96 is utilized as a versatile building block in organic synthesis to construct more complex molecules. Its presence in various chemical reactions contributes to the formation of advanced materials and compounds with specific properties for different applications.

InChI:InChI=1/C8H4BrF/c1-2-6-3-4-7(9)5-8(6)10/h1,3-5H

Upstream product

• 105931-73-5 1-bromo-3-fluoro-4-iodobenzene 

Downstream Products

• 1372603-13-8 4-(4-bromo-2-fluorophenyl)-1-(1-(dibenzo[b,d]thiophen-2-yl)ethyl)-1H-1,2,3-triazole 
• 1396007-67-2 1-{3'-fluoro-4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-[1,2,3]triazole-4-yl]biphenyl-4-yl}cyclopropanecarboxylic acid 
• 1396008-19-7 (4-bromo-2-fluorophenyl)propynoic acid ethyl ester 
• 625446-22-2 4-bromo-2-fluoroacetophenone 

Relevant articles and documents

Design, synthesis, and biological evaluation of novel 2′-methyl-2′-fluoro-6-methyl-7-alkynyl-7-deazapurine nucleoside analogs as anti-Zika virus agents

Zika virus (ZIKV) is a mosquito-borne flavivirus and outbreaks of ZIKV have been reported in Africa, Americas and other parts of the world lately. The ZIKV epidemic has received extensive attention due to its ability to cause serious medical consequences and complications such as microcephaly and Guillain-Barre syndrome in recent years. Up to now, there are no specific treatments or vaccines available for ZIKV infection, which highlights the urgent need for developing new therapies. In this work, we designed and synthesized a series of novel 6-methyl-7-acetylenenyl-7-deazapurine nucleoside analogs as potential inhibitors of ZIKV replication. The biological activities against ZIKV replication were evaluated and the structure-activity relationship (SAR) was also studied. Among the compounds evaluated, nucleoside analog 38 (EC50 = 2.8 ± 0.8 μM, EC90 = 6.8 ± 2.3 μM) showed the most potent anti-ZIKV activity with low cytotoxicity (CC50 = 54.1 ± 6.9 μM) in an A549 based cellular model. The inhibitory activity of 38 was about 5 times more potent than the positive control NITD008. Notably, 38 showed similar inhibition potency against different ZIKV strains (ZG-01 and MR766) in a variety of host cell types including SNB19, A549, Huh7, Vero. In addition, 38 (Kd = 1.87 μM) has a stronger affinity to ZIKV RNA-dependent RNA polymerase (RdRp) protein than NITD008 (Kd = 3.43 μM) in the non-phosphorylation assay. These results indicated that compound 38 may serve as a promising candidate in future anti-ZIKV drug discovery.

ALKYNYL SUBSTITUTED PYRIMIDINYL-PYRROLES ACTIVE AS KINASES INHIBITORS

The present invention relates to alkynyl substituted pyrimidinyl-pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak and/or Src fa