302934-23-2Relevant academic research and scientific papers
Enantioselective generation of benzylic stereocenters mediated by a remote sulfoxide
Garcia Ruano, Jose L.,Carreno, M. Carmen,Toledo, Miguel A.,Aguirre, Jose M.,Aranda, M. Teresa,Fischer, Jean
, p. 2736 - 2737 (2007/10/03)
Ortho-Sulfinyl-substituted benzyllithium reagents react with aldehydes and ketones to afford, after desulfurization with Raney-Nickel, stereoselective access to benzylic stereocenters [Eq. (1)]. This is the first efficient asymmetric 1,4-induction with mediation by a sulfoxide group. LDA = lithium diisopropylamide; Tol = tolyl; TIPS = triisopropylsilyl.
