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AURORA 15361 is a chemical compound that functions as a potent and selective inhibitor of the enzyme poly(ADP-ribose) polymerase (PARP), which is instrumental in DNA repair mechanisms. AURORA 15361 has demonstrated the ability to augment the efficacy of chemotherapy and radiation therapy in cancer treatment by inhibiting the repair of DNA damage within cancer cells. Additionally, it has been considered for its potential in addressing other diseases, such as cardiovascular and neurodegenerative disorders, making AURORA 15361 a promising candidate for further research and drug development in various medical fields.

302952-79-0

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Basic information
1. Product Name: AURORA 15361
2. Synonyms: OTAVA-BB BB0109350065;AURORA 15361;7-hydroxy-3-(4-methoxyphenoxy)-2-(trifluoromethyl)-4H-chromen-4-one;4H-1-benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenoxy)-2-(t;7-hydroxy-3-(4-methoxyphenoxy)-2-(trifluoromethyl)-4-chromenone;7-hydroxy-3-(4-methoxyphenoxy)-2-(trifluoromethyl)chromen-4-one;7-hydroxy-3-(4-methoxyphenoxy)-2-(trifluoromethyl)chromone;BIM-0047044.P001
3. CAS NO:302952-79-0
4. Molecular Formula: C₁₇H₁₁F₃O₅
5. Molecular Weight: 352.26
6. EINECS: N/A
7. Product Categories: N/A
8. Mol File: 302952-79-0.mol
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: 426.5°C at 760 mmHg
3. Flash Point: 211.7°C
4. Appearance: /
5. Density: 1.479g/cm³
6. Vapor Pressure: 7.11E-08mmHg at 25°C
7. Refractive Index: 1.581
8. Storage Temp.: N/A
9. Solubility: N/A
10. CAS DataBase Reference: AURORA 15361(CAS DataBase Reference)
11. NIST Chemistry Reference: AURORA 15361(302952-79-0)
12. EPA Substance Registry System: AURORA 15361(302952-79-0)
Safety Data
1. Hazard Codes: T
2. Statements: 25
3. Safety Statements: 45
4. RIDADR: UN 2811 6.1 / PGIII
5. WGK Germany: 3
6. RTECS:
7. HazardClass: IRRITANT
8. PackingGroup: N/A
9. Hazardous Substances Data: 302952-79-0(Hazardous Substances Data)

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302952-79-0 Usage

Uses

Used in Oncology:
AURORA 15361 is used as an adjunct to chemotherapy and radiation therapy for enhancing their effectiveness in cancer treatment. It serves as a PARP inhibitor, preventing the repair of DNA damage in cancer cells, thereby increasing the susceptibility of these cells to therapeutic agents and leading to improved patient outcomes.
Used in Pharmaceutical Research:
In the research industry, AURORA 15361 is utilized for studying the role of PARP enzymes in DNA repair and the development of cancer. It aids in understanding the mechanisms of action and potential synergies with other therapeutic agents, contributing to the advancement of cancer treatment strategies.
Used in Drug Development:
AURORA 15361 is employed in the development of new drugs targeting the PARP enzyme, with the aim of creating novel therapeutic options for cancer patients. Its role in inhibiting DNA repair makes it a valuable component in the creation of targeted cancer therapies.
Used in the Treatment of Other Diseases:
Beyond oncology, AURORA 15361 is studied for its potential applications in treating cardiovascular and neurodegenerative disorders. Its mechanism of action in DNA repair inhibition may offer insights into the treatment of these conditions, expanding its utility across different areas of medicine.

Check Digit Verification of cas no

The CAS Registry Mumber 302952-79-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,2,9,5 and 2 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 302952-79:
(8*3)+(7*0)+(6*2)+(5*9)+(4*5)+(3*2)+(2*7)+(1*9)=130
130 % 10 = 0
So 302952-79-0 is a valid CAS Registry Number.

InChI:InChI=1/C17H11F3O5/c1-23-10-3-5-11(6-4-10)24-15-14(22)12-7-2-9(21)8-13(12)25-16(15)17(18,19)20/h2-8,21H,1H3

302952-79-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name	7-hydroxy-3-(4-methoxyphenoxy)-2-(trifluoromethyl)chromen-4-one

1.2 Other means of identification

Product number	-
Other names	7-hydroxy-3-(4-methoxyphenoxy)-2-(trifluoromethyl)-4H-chromen-4-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:302952-79-0 SDS

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302952-79-0Relevant academic research and scientific papers

CHROMENONE DERIVATIVES FOR TREATMENT OF CANCER

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Page/Page column 15; 16, (2010/12/18)

4-Chromenone derivatives of the formula I herein that inhibit the ubiquitin-mediated degradation of p27, are useful for the treatment of cancer.

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