302953-35-1

Basic information

• Product Name: C₁₄H₁₀N₂O₂S
• CAS NO: 302953-35-1
• Molecular Weight: 270.312
• Mol File: 302953-35-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₀N₂O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₀N₂O₂S(302953-35-1)
• EPA Substance Registry System: C₁₄H₁₀N₂O₂S(302953-35-1)

Safety Data

• Hazardous Substances Data: 302953-35-1(Hazardous Substances Data)

Upstream product

• 88-14-2 2-furanoic acid 
• 39136-63-5 5-phenyl-1,3-thiazol-2-amine 

Relevant articles and documents

Identification of KPNB1 as a Cellular Target of Aminothiazole Derivatives with Anticancer Activity

We found that aminothiazole derivative (E)-N-(5-benzylthiazol-2-yl)-3-(furan-2-yl)acrylamide (1) has strong anticancer activity, and undertook proteomics approaches to identify the target protein of compound 1, importin β1 (KPNB1). A competitive binding assay using fluorescein-labeled 1 showed that 1 has strong binding affinity for KPNB1 (Kd: ～20 nm). Furthermore, through western blotting assays for KPNB1, KPNA2, EGFR, ErbB2, and STAT3, we confirmed that 1 has inhibitory effects on the importin pathway. KPBN1 appears to be overexpressed in several cancer cells, and siRNA-induced inhibition of KPNB1 shows significant inhibition of cancer cell proliferation, while leaving non-cancerous cells unaffected. Therefore, compound 1 is a promising new lead for the development of KPNB1-targeted anticancer agents. Fluorescein-labeled 1 could be a useful quantitative probe for the development of novel KPNB1 inhibitors.