302964-27-8Relevant articles and documents
Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56Lck inhibitors
Chen, Ping,Norris, Derek,Das, Jagabandhu,Spergel, Steven H.,Wityak, John,Leith, Leslie,Zhao, Rulin,Chen, Bang-Chi,Pitt, Sidney,Pang, Suhong,Shen, Ding Ren,Zhang, Rosemary,De Fex, Henry F.,Doweyko, Arthur M.,McIntyre, Kim W.,Shuster, David J.,Behnia, Kamelia,Schieven, Gary L.,Barrish, Joel C.
, p. 6061 - 6066 (2004)
A series of substituted 2-(aminoheteroaryl)-thiazole-5-carboxamide analogs have been synthesized as novel, potent inhibitors of the Src-family kinase p56Lck. Among them, compound 2 displayed superior in vitro potency and excellent in vivo efficacy. A series of substituted 2-(aminoheteroaryl)- thiazole-5-carboxamide analogs have been synthesized as novel, potent inhibitors of the Src-family kinase p56Lck. Among them, compound 2 displayed superior in vitro potency and excellent in vivo efficacy.
