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γ-(m-Nitrophenoxy)-butyrylchlorid, also known as 4-(m-nitrophenoxy)butanoyl chloride, is a chemical compound with the molecular formula C10H10ClNO4. It is a colorless to pale yellow liquid that is soluble in organic solvents. γ-(m-Nitrophenoxy)-butyrylchlorid is an important intermediate in the synthesis of various pharmaceuticals and agrochemicals, particularly those containing the m-nitrophenoxybutyryl moiety. It is synthesized by reacting m-nitrophenol with butyryl chloride in the presence of a base, such as pyridine. Due to its reactivity, γ-(m-nitrophenoxy)-butyrylchlorid is typically used in the preparation of esters and amides, which are key functional groups in many biologically active molecules. Handling γ-(m-Nitrophenoxy)-butyrylchlorid requires caution, as it is sensitive to moisture and can react violently with water, and it should be stored under an inert atmosphere to prevent decomposition.

30297-88-2

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30297-88-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 30297-88-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,2,9 and 7 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 30297-88:
(7*3)+(6*0)+(5*2)+(4*9)+(3*7)+(2*8)+(1*8)=112
112 % 10 = 2
So 30297-88-2 is a valid CAS Registry Number.

30297-88-2Relevant academic research and scientific papers

The discovery and optimization of novel dual inhibitors of topoisomerase ii and histone deacetylase

Zhang, Xuan,Bao, Bin,Yu, Xiuhua,Tong, Linjiang,Luo, Yu,Huang, Qingqing,Su, Mingbo,Sheng, Li,Li, Jia,Zhu, Hong,Yang, Bo,Zhang, Xiongwen,Chen, Yi,Lu, Wei

, p. 6981 - 6995 (2013/11/06)

A novel class of podophyllotoxin derivatives have been designed and synthesized based on the synergistic antitumor effects of topoisomerase II and histone deacetylase inhibitors. Their inhibitory activities towards histone deacetylases and Topo II and their cytotoxicities in cancer cell lines were evaluated. The aromatic capping group connection, linker length and zinc-binding group were systematically varied and preliminary conclusions regarding structure-activity relationships are discussed. Among all of the synthesized hybrid compounds, compound 24d showed the most potent HDAC inhibitory activity at a low nanomolar level and exhibited powerful antiproliferative activity towards HCT116 colon carcinoma cells at a low micromolar level. Further exploration of this series led to the discovery of potent dual inhibitor 32, which exhibited the strongest in vitro cytotoxic activity.

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