303050-39-7

Upstream product

• 118380-03-3 methyl 3-(4-acetamidophenyl)propanoate 
• 1197-55-3 4-aminophenylacetic acid 
• 39552-81-3 methyl p-aminophenylacetate 
• 108-24-7 acetic anhydride 

Downstream Products

• 303050-40-0 methyl 4-acetamido-3-aminophenylacetate 
• 303050-04-6 N-(4-chloro-3-methylisothiazol-5-yl)-N-(ethoxymethyl)-(2-propylbenzotriazol-5-yl)acetamide 
• 1026940-70-4 2-(4-Amino-3-nitro-phenyl)-N-((R)-5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-N-methyl-acetamide 
• 1026426-43-6 4-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-methyl-amino]-ethyl}-benzene-1,2-diamine 
• 116435-82-6 2-(4-amino-3-nitrophenyl)acetic acid 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS AS INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR

Disclosed are heterocyclic compounds as inhibitors of FGFR-4 represented by formula (I). Also disclosed is a pharmaceutical composition that includes an inhibitor of FGFR-4. The compounds maybe used to treat diseases mediated with abnormality of FGFR-4 and /or FGF19, such as hepatocellular carcinoma and other forms of cancer.

PESTICIDAL INDAZOLE OR BENZOTRIAZOLE DERIVATIVES

A compound of formula (I) wherein G is either (i) or (ii), where M1 or M2 is bonded to A; n is 0 or 1; when G is (i), D is S, NR7, CR8-CR9, CR8-N, CR8-N(O), N-CR9 or N(O)-CR9; when G is (ii), D is S or NR7; E is N, N-oxide or CR10; M1 is OC(-Y), N(R11)C(-Y), N-C(OR12), N-C(SR13) or N-C(NR14R15) where O or N is the atom of attachment to the ring containing D and E; M2 is N-C(-Y) where N is the atom of attachment to the ring containing D and E; Y is O, S or NR16; J is N or CR17; and A, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14 and R15 are each certain organic or inorganic groups. These compounds are useful in fungicidal, insecticidal, acaricidal, molluscicidal and hematicidal compositions.

Structure-activity studies for a novel series of N-(arylethyl)-N- (1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamines possessing dual 5- HT uptake inhibiting and α2-antagonistic activities

In search of an α2-antagonist/5-HT uptake inhibitor as a potential new class of antidepressant with a more rapid onset of action, compound 3 was prepared and observed to possess high affinity for the α2-receptor (K(i) = 6.71 nM) and