303121-20-2Relevant academic research and scientific papers
Enzyme and photoredox sequential catalysis for the synthesis of 1,3-oxazine derivatives in one pot
Zhang, Guo-Yan,Xiang, Yang,Guan, Zhi,He, Yan-Hong
, p. 1937 - 1942 (2017/07/15)
A novel strategy combining visible-light and enzyme catalysis in one pot for the synthesis of 1,3-oxazine derivatives from α- or β-naphthols and ethyl N-aryl glycinates is described for the first time. Various 1,3-oxazine derivatives were prepared with yields of up to 69% under mild reaction conditions by a simple operation. This approach consists of sequential enzymatic hydrolysis and visible-light excited decarboxylation of ethyl N-aryl glycinates, oxidation of α-amino radicals, Mannich reaction, transimination and intramolecular cyclization. This work provides a novel alternative method for the synthesis of 1,3-oxazine derivatives.
Polyethylene glycol (PEG) mediated expeditious synthetic route to 1,3-oxazine derivatives
Shinde, Pravin V.,Kategaonkar, Amol H.,Shingate, Bapurao B.,Shingare, Murlidhar S.
experimental part, p. 915 - 918 (2012/01/11)
Various 1,3-oxazine derivatives were synthesized in high yields, within shorter reaction times using PEG-400 as a safer medium/mediator. This synthetic route is exceedingly easy and avoids the use of acid/base catalysts.
An efficient one-pot strategies for the synthesis of [1,3] oxazine derivatives
Sapkal, Suryakant B.,Shelke, Kiran F.,Shingate, Bapurao B.,Shingare, Murlidhar S.
experimental part, p. 437 - 442 (2010/10/19)
Sodium hydrogen sulphate (NaHSO4), n-tetra butyl ammonium bromide (TBAB) as a phase transfer catalyst (PTC) in water, and 1-butyl-3-methyl imidazolium hydrogen sulphate [bmim]HSO4 as ionic liquid (IL) has been used as a mild reaction promoter for the cyclocondensation of formalin, β-naphthol and aromatic amines to afford respective 2,3-dihydro-2-phenyl- 1H-naphtho-[1,2-e] [1,3] oxazine derivatives. The present protocols are greener, high yielding and involved the nonchromatographic isolation procedure.
