303128-79-2Relevant academic research and scientific papers
Synthesis of novel 16-spiro steroids: Spiro-7′-(aryl)tetrahydro-1H- pyrrolo[1,2-c][1,3]thiazolo-trans-androsterone hybrid heterocycles
Kanchithalaivan, Selvaraj,Kumar, Raju Ranjith,Perumal, Subbu
, p. 409 - 417 (2013/04/23)
The 1,3-dipolar cycloaddition of azomethine ylide derived in situ from the reaction of acenaphthylene-1,2-dione and 1,3-thiazolane-4-carboxylic acid to various exocyclic dipolarophiles synthesized from trans-androsterone and trans-dehydroandrosterone afforded a library of novel spiro[5′.2″] acenaphthylene-1″-one-spiro[16.6′]-(7′-aryl) -tetrahydro-1H-pyrrolo [1,2-c][1,3]thiazolo-trans-androsterone/ dehydroandrosterone hybrid heterocycles respectively. These reactions proceeded stereo-specifically affording a single isomer of the 16-spiro steroids in excellent yields.
Synthesis, characterization and biological evaluation of some 16E-arylidene androstane derivatives as potential anticancer agents
Guo, Hao,Wu, Haotian,Yang, Jin,Xiao, Yuling,Altenbach, Hans-Josef,Qiu, Guofu,Hu, Hao,Wu, Zhongyuan,He, Xianran,Zhou, Dingshan,Hu, Xianming
experimental part, p. 709 - 723 (2011/07/07)
A series of new 16E-arylidene androstane derivatives were synthesized and characterized. The new compounds were screened for their anticancer activities against the human cancer cell lines SW480, A549, HepG2 and HeLa in vitro using the MTT assay. The resu
Peracid Oxidation of 16-Arylidene- and 16-Alkylidene-17-oxo-steroids
Chagonda, Lameck S.,Marples, Brian A.
, p. 875 - 880 (2007/10/02)
Peracid oxidation of 16-arylidene- and 16-alkylidene-5α-androstan-17-ones (1) - (6) gave no α,β-unsaturated δ-lactones, but resulted mainly in products of direct oxidation of the olefinic double bond.
