303134-11-4

Usage

InChI:InChI=1/C12H15N3/c13-10-11-2-4-12(5-3-11)15-8-1-6-14-7-9-15/h2-5,14H,1,6-9H2

Upstream product

• 112275-50-0 tert-butyl 1,4-diazepine-1-carboxylate 
• 1194-02-1 4-fluorobenzonitrile 
• 868063-74-5 4-(4-cyanophenyl)-1,4-diazepane-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1291057-88-9 4-[4-(3-benzo[b]thiophen-3-yl-3-hydroxypropyl)-[1,4]-diazepan-1-yl]benzonitrile 
• 1291057-75-4 4-[4-(3-benzo[b]thiophen-3-yl-3-oxopropyl)-[1,4]-diazepan-1-yl]benzonitrile hydrochloride 
• 1428557-48-5 C₂₀H₂₂N₆O₂S 
• 868063-73-4 3-amino-4-[4-(4-cyanophenyl)-1,4-diazepan-1-yl]thieno[2,3-b]pyridine-2-carboxamide 
• 868063-75-6 (Z)-2-cyano-3-[4-(4-cyanophenyl)-1,4-diazepan-1-yl]but-2-enethioamide 

Relevant academic research and scientific papers

Discovery and structure-activity relationship of thienopyridine derivatives as bone anabolic agents

A cell-based assay was performed for the discovery of novel bone anabolic agents. Alkaline phosphatase (ALPase) activity of ST2 cells was utilized as an indicator of osteoblastic differentiation, and thienopyridine derivative 1 was identified as a hit compound. 3-Aminothieno[2,3-b]pyridine-2-carboxamide was confirmed to be a necessary core structure for the enhancement of ALPase activity, and then optimization of the C4-substituent on the thienopyridine ring was carried out. Introduction of cyclic amino groups to the C4-position of the thienopyridine ring improved the activity. Especially, N-phenyl-homopiperazine derivatives were found to be strong enhancers of ALPase among this new series. Furthermore, 3-amino-4-(4-phenyl-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2- carboxamide (15k) was orally administered to ovariectomized (OVX) rats over 6 weeks for evaluating the effects on areal bone mineral density (aBMD), and statistically significant improvements in aBMD were observed from the dosage of 10 mg/kg/day.

Novel benzo[ b ]thiophene derivatives as new potential antidepressants with rapid onset of action

We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT7R and 5-HTT were selected to probe their antidepressant activity in vivo using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action.

THIENOPYRIDINE DERIVATIVES

The present invention provides a compound promoting osteogenesis. The present invention provides a compound having the following general formula (I) wherein R 1 is H or alkyl, R 2 is R a S-, R a O-, R a NH-, R a (R b )N- or cyclic amino, and R a and R b are alkyl which may be substituted, cycloalkyl which may be substituted, or the like, or a pharmacologically acceptable salt thereof.