303165-20-0

Basic information

• Product Name: (+/-)-[3,4-bis(difluoromethoxy)phenyl]-(2-bromopyridin-5-yl)methanol
• Synonyms: (+/-)-[3,4-bis(difluoromethoxy)phenyl]-(2-bromopyridin-5-yl)methanol
• CAS NO: 303165-20-0
• Molecular Weight: 396.136
• Mol File: 303165-20-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (+/-)-[3,4-bis(difluoromethoxy)phenyl]-(2-bromopyridin-5-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-[3,4-bis(difluoromethoxy)phenyl]-(2-bromopyridin-5-yl)methanol(303165-20-0)
• EPA Substance Registry System: (+/-)-[3,4-bis(difluoromethoxy)phenyl]-(2-bromopyridin-5-yl)methanol(303165-20-0)

Safety Data

• Hazardous Substances Data: 303165-20-0(Hazardous Substances Data)

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 127842-54-0 3,4-bis-(difluoromethoxy)-benzaldehyde 

Downstream Products

• 306761-03-5 {5-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-pyridin-2-yl}-(1-methyl-1-phenyl-ethyl)-carbamic acid benzyl ester 
• 306760-71-4 {5-[1-(3,4-bis-difluoromethoxy-phenyl)-2-pyridin-4-yl-ethyl]-pyridin-2-yl}-(1-methyl-1-phenyl-ethyl)-carbamic acid benzyl ester 
• 306760-68-9 4-{2-[3,4-Bis(difluoromethoxy)phenyl]-2-[6-(N-benzyl trifluoroacetamido)pyridin-3-yl]ethyl}pyridine 
• 306761-01-3 {5-[(3,4-bis-difluoromethoxy-phenyl)-hydroxy-methyl]-pyridin-2-yl}-(1-methyl-1-phenyl-ethyl)-carbamic acid benzyl ester 
• 306760-02-1 {5-[1-(3,4-bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-pyridin-2-yl}-(1-methyl-1-phenyl-ethyl)-amine 

Relevant articles and documents

Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: Structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity

A SAR study on the tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors related to 1 is described. In addition to inhibitory potency against PDE4 and the lipopolysaccharide-induced production of TNFα in human whole blood, the binding affinity

HETEROSUBSTITUTED PYRIDINE DERIVATIVES AS PDE 4 INHIBITORS

The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE 4)