30318-36-6Relevant academic research and scientific papers
Base-induced rearrangement of O-benzoylbenzaldehyde cyanohydrin to benzil and the further reactions of benzil
Zheng, Zi-Rong,Kjaer, Niels Them,Lund, Henning
, p. 362 - 365 (2007/10/03)
O-Benzoylbenzaldehyde cyanohydrin has been found to form benzil in DMF in a base-catalysed reversible reaction. The possibility of using the reaction for the synthesis of unsymmetrical benzils from an aldehyde derivative and an acid derivative was investigated, but such a synthesis was made invalid by the further reaction of benzil with strong bases. The reaction of benzil with potassium tertbutoxide in DMF gave several products, among which the formation of two of them involved the anion of DMF and the formation of others included redox reactions. Acta Chemica Scandinavica 1998.
α-Keto Amides and 1,2-Diketones from N,N'-Dimethoxy-N,N'-dimethylethanediamide. A Synthetic and Mechanistic Investigation
Sibi, Mukund P.,Marvin, Mali,Sharma, Rajiv
, p. 5016 - 5023 (2007/10/03)
N,N'-Dimethoxy-N,N'-dimethylethanediamide (1), a 1,2-dicarbonyl synthon prepared from oxalyl chloride, undergoes nucleophilic displacements with Grignard reagents to provide α-keto amides 2-12 in 28-90percent yields.The synthon also undergoes double nucleophilic displacements with organolithium reagents to furnish symmetrical 1,2-diketones 15-23 in 15-84percent yields.A mechanism accounting for all the products from the reaction of 1 with nucleophiles has been proposed.Several control experiments were carried out to support the proposed mechanism.
Single-electron Transfer-initiated Thermal Reactions of Arylmethyl Halides, IX. The Reaction of 2-Bromo-N,N-dimethyl-2,2-diphenylacetamide with Triethylamine in Benzene
Simig, Gyula,Toth, Gabor
, p. 1273 - 1277 (2007/10/02)
Das Halogenamid 1a liefert mit Triethylamin in siedendem Benzol 41-48percent des Dimeren 3 als Hauptprodukt.Andererseits fuehrt die Thermolyse von 1f in Benzol in Gegenwart von Triethylamin zu 1c und 8a.Die Bildung von 3 erfolgt ueber die Radikale 4, die ihrerseits das Produkt einer Ein-Elektronen-Uebergangs-Reaktion mit Triethylamin als Elektron-Donor sind.Der Uebergang der Radikale 4 in das Dimere 3 verlaeuft entsprechend der Reaktionsfolge (2)+(4)+(5) (carbanionischer Mechanismus der Dimeren-Bildung).
Single-electron Transfer-initiated Thermal Reactions of Arylmethyl Halides. Part 8. The Reaction of 2-Halogeno-NN-dimethyl-2,2-diphenylacetamides with Sodium Methoxide in 2,2-Dimethoxypropane. The Effects of Added Acetone, Temperature Elevation, and of the Nature of the Halogen. Refin...
Lempert, Karoly,Simig, Gyula,Tamas, Jozsef,Toth, Gabor
, p. 1927 - 1936 (2007/10/02)
In addition to the previously isolated products (1c) and (2a), trimeric (2b) and oligomeric products (2c) were shown to result from the title reaction.The reactions leading to all these products are initiated by single-electron transfer (SET) to the halogenoacetamides (1a and b).The operation of chain processes is established (Scheme 4).Acetone enolate is shown to be a more effective single-electron donor towards compound (1a) than methoxide.In the absence of acetone enolate SN reactions with methoxide compete with SET-initiated reactions of compound (1a) at room temperature.Temperature elevation favours SET over SN reactions.The mechanism of trimer (2b) and oligomer (2c) formation is discussed and, in addition to the radical recombination mechanism, the carbanionic mechanism of dimer (2a) formation is established.The chloro derivative (1b) is shown to be less reactive in the title reaction than the bromo analogue (1a).
