303186-36-9

Usage

Preparation

The preparation of PGUQU 3F is as follows:1.00 g (2.90 mmol) of?5-[4-chloro-2,6-difluorophenyl)difluoromethoxy]-1,2,3-trifluorobenzene and 0.764 g (2.96 mmol, 1.02 equivalent amount) of 4'-propyl-3-fluoro-4-biphenylboronic acid were placed in a 50-ml SUS autoclave, after which 46.7 mg (0.05 equivalent amount) of TBAB, 1.10 mg (0.0008 equivalent amount) of 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl (purchased from Johnson Matthey Japan Inc.), and 4.94 mg (0.0004 equivalent amount) of 5% palladium carbon (50% moisture content, manufactured by N.E. Chemcat Corporation; E-Type) were placed in the autoclave. The autoclave was subsequently sealed, and the atmosphere therein was replaced with nitrogen. Thereafter, 3.0 ml of deaerated water and 1.0 ml of deaerated DMAC were added thereto, and 0.44 g (1.5 equivalent amount) of triethylamine was further added thereto, followed by stirring at the reaction liquid temperature of 95°C for 3 hours. The mixture was stirred at room temperature for 20 minutes, and 5.0 ml of toluene and 2.0 ml of water were added to the reaction mixture, followed by additional stirring for 15 minutes. The reaction yield was 99.4% (quantified by 19F NMR).

Upstream product

• 958654-11-0 3-fluoro-4-iodo-4'-propylbiphenyl 
• 1052241-53-8 C₂₂H₁₆BrF₅ 
• 99627-05-1 3,4,5-trifluorophenol 
• 156545-07-2 3,5-difluorophenylboronic acid 
• 909709-42-8 2-fluoro-4-(4-propylphenyl)phenylboronic acid 

Relevant academic research and scientific papers

Novel liquid crystalline four ring chain difluoromethyleneoxy compounds for quicker response LC mixtures

A series of chemically stable novel liquid crystalline four ring chain compounds (1a-1c) having a difluoromethyleneoxy (CF2O) linkage moiety have been designed and prepared, and their properties have been thoroughly investigated. The novel compounds intrinsically possess much higher positive Δε (>32) and Dn (>0.190), relatively low viscosity, wider nematic phase temperature ranges and significantly higher clearing temperatures in comparison to the analogous three ring chain CF2O compound (2) that is currently applied in almost all the latest TN-TFT monitors, notebook PCs and IPS-TVs. Copyright Taylor & Francis Group, LLC.

Process for producing fluorine-containing biaryl compound

The present invention relates to a process comprising: reacting an aromatic boronic acid compound comprising a fluorine atom at the ortho position or a cyclic trimer thereof with an aromatic chloride represented by a specific formula in a water-containing solvent under heating, in the presence of a palladium catalyst and a tertiary amine compound; this process allows a fluorine-containing biaryl compound to be obtained in a high reaction yield.

LIQUID CRYSTAL COMPOUND HAVING DIFLUOROPROPENYLENEOXY BONDING GROUP

The invention provides a liquid crystal compound having general physical properties necessary for the compound, namely stability to heat, light and so forth, a wide temperature range of a liquid crystal phase, a high clearing point, a good compatibility w