303188-52-5Relevant academic research and scientific papers
The synthesis of 4-arylsulfanyl-substituted kainoid analogues from trans-4-hydroxy-L-proline
Baldwin, Jack E,Pritchard, Gareth J,Williamson, Douglas S
, p. 7991 - 7997 (2007/10/03)
The potent neuroexcitatory activity of kainoid amino acids in the mammalian CNS places new analogues in high demand as tools for neuropharmacological research. A range of 4-arylsulfanyl-substituted kainoids has been synthesised in a parallel fashion via mesylate displacement by a number of aromatic thiolates upon (2S,3S,4R)-1-benzoyl-3-tert-butoxycarbonylmethyl-4- methanesulfonyloxypyrrolidine-2-carboxylic acid methyl ester 9, which is obtainable in eight steps from trans-4-hydroxy-L-proline 5.
The synthesis of 4-Arylsulfanyl-Substituted Kainoid analogues from trans-4-Hydroxy-L-proline
Baldwin, Jack E.,Pritchard, Gareth J.,Williamson, Douglas S.
, p. 1927 - 1929 (2007/10/03)
The potent neuroexcitatory activity of kainoid amino acids in the mammalian CNS places new analogues in high demand as tools for neuropharmacological research. A range of 4-arylsulfanyl-substituted kainoids has been synthesised in a parallel fashion via mesylate displacement by a number of aromatic and heteroaromatic thiolates upon (2S,3S,4R)-1-benzoyl-3-tert-butoxycarbonylmethyl-4-methanesulfony loxy pyrrolidine-2-carboxylic acid methyl ester 8, which is obtainable in eight steps from trans-4-hydroxy-L-proline 5. (C) 2000 Elsevier Science Ltd.
