303206-65-7Relevant academic research and scientific papers
Acylhydrazone derivatives as potential anticancer agents: Synthesis, bio-evaluation and mechanism of action
Yu, Xifang,Shi, Liqiao,Ke, Shaoyong
, p. 5772 - 5776 (2015/11/24)
A series of novel acylhydrazone derivatives were designed, synthesized and evaluated for their potential cytotoxic effects against human cancer cell lines. The preliminary results indicated that some of the obtained compounds (such as 8b, 13c) exhibited good to moderate cytotoxic activities against human HepG2, Huh-7, and BCG-823 cell lines. Especially, compounds 8c and 8e presented obviously selective cytotoxic activities against Huh-7 in vitro (8c, IC50 = 7.74 ± 2.18 μg/mL; 8e, IC50 = 4.46 ± 1.05 μg/mL) compared to 5-FU (IC50 = 10.41 ± 3.41 μg/mL). The highly potential compounds to induce apoptosis in HepG2 cells were analyzed by flow cytometry, and the apoptotic effects of compounds 8b and 13c were further evaluated using Annexin V-FITC/propidium iodide dual staining assay.
Rapid and efficient synthesis of some biological active 2-azetidinones under microwave irradiation
Desai,Desai
, p. 2093 - 2096 (2007/10/03)
An efficient and extremely fast procedure for the synthesis of 4-aryl-3-chloro-1-[(2-benzothiazolylthio)acetamidyl]-2-azetidinone 4 by the reaction of arylidene-[(2-benzothiazolylthio)acetamidyl] 3 with chloroacetylchloride in DMF in the presence of catal
Synthesis and biological activity of 4-oxothiazolidines and their 5-arylidenes
Srivastava,Yadav,Srivastava
, p. 399 - 405 (2007/10/03)
A series of 5-arylidene-2-aryl-3-[(2-benzothiazolylthio)-acetamidyl]-1,3-thiazolidin-4-ones have been synthesised by appropriate methods. All the compounds have been screened for their antifungal activity against Candida albicans, Fusarium heterosporium a
