30335-67-2

Basic information

• Synonyms: 5-Bromo-2-nitrobenzofuran
• CAS NO: 30335-67-2
• Molecular Formula: C₈H₄BrNO₃
• Molecular Weight: 242.02626
• Mol File: 30335-67-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 333°C at 760 mmHg
• Flash Point: 155.2°C
• Appearance: /
• Density: 1.801g/cm³
• Vapor Pressure: 0.000273mmHg at 25°C
• Refractive Index: 1.677
• CAS DataBase Reference: N/A(CAS DataBase Reference)
• NIST Chemistry Reference: N/A(30335-67-2)
• EPA Substance Registry System: N/A(30335-67-2)

Safety Data

• Hazardous Substances Data: 30335-67-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H4BrNO3/c9-6-1-2-7-5(3-6)4-8(13-7)10(11)12/h1-4H

Upstream product

• 96089-31-5 2-nitro-3-hydroxy-2,3-dihydrobenzofuran 
• 96089-31-5 cis-5-bromo-3-hydroxy-2-nitro-2,3-dihydrobenzofuran 
• 96089-31-5 trans-5-bromo-3-hydroxy-2-nitro-2,3-dihydrobenzofuran 
• 99203-89-1 trans-3-acetoxy-5-bromo-2-nitro-2,3-dihydrobenzofuran 
• 99203-89-1 cis-3-acetoxy-5-bromo-2-nitro-2,3-dihydrobenzofuran 
• 116833-59-1 cis-5-bromo-3-hydroxy-2-nitro-2,3-<2-D>dihydrobenzofuran 
• 116833-59-1 trans-5-bromo-3-hydroxy-2-nitro-2,3-<2-D>dihydrobenzofuran 
• 563-70-2 bromonitromethane 
• 1761-61-1 5-bromosalicyclaldehyde 
• 14268-23-6 potassium trinitromethanide 
• 96853-37-1 4-Bromo-2-(2-nitro-ethyl)-phenol 
• 61131-72-4 2-(2-nitrovinyl)-4-bromophenol 

Relevant articles and documents

An Improved Synthesis of 2-Nitrobenzofurans

2-Nitrobenzofurans 4 are prepared in improved yields by reacting o-hydroxybenzaldehydes 1 and bromonitromethane (2) at low temperature in order to avoid the dehydration of the aldol intermediate 3 in the alkaline condensation medium.This aldol 3 is then quantitatively dehydrated by heating in acetic anhydride.

Asymmetric dearomatization of 2-nitrobenzofurans by organocatalyzed one-step Michael addition to access 3,3′-disubstituted oxindoles

An efficient enantioselective dearomatization of 2-nitrobenzofurans was realized via an organocatalyzed one-step Michael addition process. This method provides a facile strategy to access a range of structurally diverse 3,3′-disubstituted oxindoles, which feature an intriguing combination of two privileged motifs including 3-pyrrolyl-substituted-oxindoles and 2,3-dihydrobenzofurans substructures, in excellent results.

Facile synthesis of chiral [2,3]-fused hydrobenzofuran: Via asymmetric Cu(i)-catalyzed dearomative 1,3-dipolar cycloaddition

Intermolecular asymmetric dearomative 1,3-dipolar cycloaddition of 2-nitrobenzofurans with azomethine ylides was enabled by using a chiral Cu(i)/(S,Sp)-iPr-Phosferrox catalyst. As a result, a series of highly stereoselective chiral [2,3]-fused hydrobenzofurans possessing four contiguous stereogenic centers were obtained with good to high yields, diastereoselectivities and enantioselectivities. The reaction has broad substrate scope tolerating various functional groups.