30338-85-3Relevant academic research and scientific papers
Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: Development of novel spiropiperidines
Burgey, Christopher S.,Potteiger, Craig M.,Deng, James Z.,Mosser, Scott D.,Salvatore, Christopher A.,Yu, Sean,Roller, Shane,Kane, Stefanie A.,Vacca, Joseph P.,Williams, Theresa M.
scheme or table, p. 6368 - 6372 (2010/05/02)
Several novel spiropiperidine-based CGRP receptor antagonists have been developed that maintain good potency and have reduced potential for metabolism.
HETEROCYCLIC BENZODIAZEPINE CGRP RECEPTOR ANTAGONISTS
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Page/Page column 50; 67, (2008/06/13)
Compounds of formula I: (where variables R2, R7, D, W, X, Y and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
CGRP RECEPTOR ANTAGONISTS
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Page/Page column 58-59, (2010/11/08)
The present invention is directed to compounds of Formula I: Formula I: I and Formula II: (where variables R1, R2, R3, R4, A, B, J, Q, T, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
CGRP RECEPTOR ANTAGONISTS
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Page/Page column 82-83; 93, (2010/11/08)
Compounds of Formula (I): and Formula (II): (where variables R2, R4, A, B, D, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
CGRP RECEPTOR ANTAGONISTS
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Page/Page column 67, (2010/11/23)
Compounds of Formula (I), (where variables R1, A, B, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
