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3034-48-8

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3034-48-8 Usage

Chemical Properties

YELLOW TO BROWN CRYSTALLINE POWDER

Uses

2-Bromo-5-nitrothiazole is used as a building block. It is used as an intermediate to produce other chemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 3034-48-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,0,3 and 4 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 3034-48:
(6*3)+(5*0)+(4*3)+(3*4)+(2*4)+(1*8)=58
58 % 10 = 8
So 3034-48-8 is a valid CAS Registry Number.
InChI:InChI=1/C3HBrN2O2S/c4-3-5-1-2(9-3)6(7)8/h1H

3034-48-8 Well-known Company Product Price

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  • Alfa Aesar

  • (A14701)  2-Bromo-5-nitrothiazole, 98%   

  • 3034-48-8

  • 1g

  • 270.0CNY

  • Detail
  • Alfa Aesar

  • (A14701)  2-Bromo-5-nitrothiazole, 98%   

  • 3034-48-8

  • 5g

  • 1104.0CNY

  • Detail
  • Alfa Aesar

  • (A14701)  2-Bromo-5-nitrothiazole, 98%   

  • 3034-48-8

  • 25g

  • 4875.0CNY

  • Detail
  • Aldrich

  • (B74372)  2-Bromo-5-nitrothiazole  98%

  • 3034-48-8

  • B74372-1G

  • 333.45CNY

  • Detail
  • Aldrich

  • (B74372)  2-Bromo-5-nitrothiazole  98%

  • 3034-48-8

  • B74372-5G

  • 1,359.54CNY

  • Detail

3034-48-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-bromo-5-nitro-1,3-thiazole

1.2 Other means of identification

Product number -
Other names THIAZOLE,2-BROMO-5-NITRO

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3034-48-8 SDS

3034-48-8Relevant articles and documents

Gyrase ATPase domain as an antitubercular drug discovery platform: Structure-based design and lead optimization of nitrothiazolyl carboxamide analogues

Jeankumar, Variam Ullas,Renuka, Janupally,Kotagiri, Sonali,Saxena, Shalini,Kakan, Shruti Singh,Sridevi, Jonnalagadda Padma,Yellanki, Swapna,Kulkarni, Pushkar,Yogeeswari, Perumal,Sriram, Dharmarajan

, p. 1850 - 1859 (2014)

In this study, we explored the pharmaceutically underexploited mycobacterial gyrase ATPase (GyrB) domain as a template for a structure-based virtual screening of our in-house (BITS Pilani) compound collection to discover new inhibitors targeting Mycobacterium tuberculosis (M.tb.) The hit identified was further customized by using a combination of molecular docking and medicinal chemistry strategies to obtain an optimized analogue displaying considerable in vitro enzyme efficacy and bactericidal properties against the M.tb. H 37Rv strain. The binding affinity of the ligand toward the GyrB domain was reascertained by differential scanning fluorimetry experiments. Further evaluation of the hERG toxicity (a major limitation among the previously reported N-linked aminopiperidine analogues) indicated these molecules to be completely devoid of cardiotoxicity, a significant achievement within this class.

Basic techniques of working on a solid phase: From ABC of the peptide synthesis to libraries of non-natural amino acids

Babaev,Ermolat'ev

experimental part, p. 2572 - 2589 (2011/04/15)

Libraries of hardly available amino acids bearing a heteroaromatic ring (2-pyrimidyl, substituted 2-pyridyl or 2-thiazolyl) at the amino group were prepared using solid-phase synthesis on various resins. The synthesized compounds are structurally similar to some known antidiabetic drugs. The paper combines features of a review (elementary introduction to the solid-phase synthesis methodology and technique for beginners and selected methods from peptide chemistry) and step-by-step experimental protocols (tested by the authors) useful as a methodic tool. The presented protocols (immobilization and modification of amino acids, placing and removal of common protective groups) require no sophisticated equipment and may be useful as pictorial introductory tasks for students education. Pleiades Publishing, Ltd., 2010.

Pharmaceutical compositions and methods for modulating signal transduction

-

, (2008/06/13)

The present invention relates to organic molecules capable of inhibiting protein tyrosine phosphatase activity. The invention further relates to the use of such molecules to modulate or regulate signal transduction by inhibiting protein tyrosine phosphatase activity. Finally, the invention relates to the use of such molecules to treat various disease states including diabetes mellitus.

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