30342-87-1

Upstream product

• 2231-57-4 Thiocarbohydrazide 
• 107-92-6 butyric acid 
• 79-19-6 thiosemicarbazide 
• 105-54-4 butanoic acid ethyl ester 

Downstream Products

• 139267-97-3 4-<5-(4-p-Chlorophenyl)-2-furfurylidene>amino-3-mercapto-5-propyl-1,2,4-triazole 
• 139268-15-8 6-<5-(4-Chlorophenyl)-2-furyl>-3-propyl-1,2,4-triazolo<3,4-b>-1,3,4-thiadiazole 
• 101366-96-5 5-mercapto-3-n-propyl-4-salicylideneamino-s-triazole 
• 139268-09-0 6-<5-(4-Bromophenyl)-2-furyl>-3-propyl-1,2,4-triazolo<3,4-b>-1,3,4-thiadiazole 
• 135549-14-3 8-(4-Methoxy-phenyl)-6-phenyl-3-propyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazepine 
• 139267-91-7 4-<5-(4-p-Bromophenyl)-2-furfurylidene>amino-3-mercapto-5-propyl-1,2,4-triazole 
• 623936-88-9 4-{[1-[5-(4-Methoxy-2-nitro-phenyl)-furan-2-yl]-meth-(E)-ylidene]-amino}-5-propyl-2,4-dihydro-[1,2,4]triazole-3-thione 

Relevant academic research and scientific papers

Synthesis and Biological Evaluation of 1,2,4-Triazole Thioethers as Both Potential Virulence Factor Inhibitors against Plant Bacterial Diseases and Agricultural Antiviral Agents against Tobacco Mosaic Virus Infections

Targeting the virulence factors of phytopathogenic bacteria is an innovative strategy for alleviating or eliminating the pathogenicity and rapid outbreak of plant microbial diseases. Therefore, several types of 1,2,4-triazole thioethers bearing an amide l

1,2,4-triazole-3-thione Schiff bases compounds: Crystal structure, hirshfeld surface analysis, DFT studies and biological evaluation

Three novel Schiff base compounds (G1, G2 and G3) were synthesized and characterized by elemental analysis, FT-IR, NMR, and X-ray single crystal diffraction. The crystal structures exhibit both inter- and intra-molecular h

Synthesis and biological evaluation of some novel S-β-D-glucosides of 4-amino-5-alkyl-1,2,4-triazole-3-thiones derivatives

A novel series of 3-S-β-D-glucosides-4-arylideneamino-5-alkyl-1,2,4-triazoles were designed and synthesized by reaction of 4-amino-5-alkyl-4H-1,2,4triazole-3-thiol Schiff bases and 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide. The structures of the target compounds have been characterized by 1H NMR, 13C NMR, FT-IR, and Microanalyses. All the newly synthesized compounds have been screened for their in vitro antibacterial and antifungal activities against two Gram-positive bacteria [Bacillus cereus (PTCC 1015) and Staphylococcus aureus (ATCC 25923)], two Gram-negative bacteria [Pseudomonas aeruginosa (ATCC 27853) and Escherichia coli (PTCC 1399) and two fungi [Aspergillus Niger (PTCC 5012) and Candida albicans (PTCC 5027)].

Synthesis of Novel 1,2,4-Triazole-3-thione Derivatives as Influenza Neuraminidase Inhibitors

A series of 1,2,4-triazole-3-thione derivatives (6a–6t) were synthesized and evaluated against influenza viruses (H1N1) neuraminidase (NA) in vitro. Eighteen compounds exhibited inhibitory potency with IC50 values ranging from 14.68?±?0.49 to 39.85?±?4.23?μg/mL. Among them, compounds 6e and 6h showed significant inhibitory activity with IC50 values of 14.97?±?0.70 and 14.68?±?0.49?μg/mL, respectively. Structure activity relationships were established. Molecular docking studies were performed to understand the binding interaction between active compounds and NA.

Design, Synthesis and Evaluation of Antitubercular Activity of Novel 1,2,4-Triazoles Against MDR Strain of Mycobacterium tuberculosis

Emergence of various forms of resistant strains of Mycobacterium tuberculosis led to the exploration of drugs with novel mechanism of action. Recently econazole, an azole based antitubercular agent, attracted major attention for targeting mycobacterial cytochrome P450. In the present study, we designed novel 1,2,4-triazole derivatives based on econazole moiety and evaluated them for in vitro antitubercular activity against M. tuberculosis H37Rv and multi-drug resistant (MDR) strains of Mycobacterium.

Synthesis and Biological Evaluation of Kojic Acid Derivatives Containing 1,2,4-triazole as Potent Tyrosinase Inhibitors

A series of 5-substituted-3-[5-hydroxy-4-pyrone-2-yl-methymercapto]-4-amino-1,2,4-triazole derivatives were synthesized by nucleophilic substitution reaction of 5-hydroxy-2-chloromethyl -4H-pyran-4-one with 5-substituted-3-mercapto-4-amino-1,2,4-triazole,

Synthesis, crystal structure, IR, 1H NMR and theoretical calculations of 1,2,4-triazole Schiff base

5-Propyl-4-amino-1,2,4-triazole Schiff base was characterized by FT-IR, 1H NMR and X-ray single crystal diffraction techniques. The compound crystallizes in the triclinic space group p-1 with z = 2. The molecular geometry was optimized using de

Spectral, antimicrobial, and thermal studies of some transition metal complexes derived from bidentate ligands containing N and S donor atoms

Bidentate ligands have been synthesized by the reaction of 2,4-dichlorobenzaldehyde with 4-amino-5-mercapto-1,2,4-triazole and 4-amino-5-mercapto-3-propyl-1,2,4-triazole. The ligands react with acetates of Co(II), Ni(II), Cu(II), and Zn(II) to yield 1:2 [metal:ligand] complexes. The newly synthesized compounds were characterized by elemental analyses, spectral (UV-Vis, IR, 1H NMR, fluorescence, ESR) studies, thermal techniques, and magnetic measurements. Thermal studies of the complexes showed a multistep decomposition pattern. A square planar geometry for Cu(II) and octahedral geometry for Co(II), Ni(II), and Zn(II) complexes have been proposed. The synthesized complexes exhibit enhanced antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Aspergillus niger, and A. flavus compared to parent ligands. However, tested compounds did not exhibit any activity against Escherichia coli and Pseudomonas aeruginosa. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

Synthesis of some novel 3-Alkyl/aryl-6-((1H-benzo[d][1,2,3]triazol-1-yl) methyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles

(Chemical Equation Presented) A series of 3-alkyl/aryl substituted-6-((1H- benzo[d][1,2,3]triazol-1-yl)methyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadizoles 4a-m are prepared by the condensation of 3-alkyl/aryl substituted-4-amino-5- mercapto-1,2,4-triazoles 2a-m with benzotriazole-1-yl acetic acid 3 through a single step reaction. The structures of all newly synthesized compounds are established on the basis of their IR, 1H NMR, and elemental analyses data. Two selected compounds 4l and 4m are investigated for their analgesic and anti-inflammatory activities; they showed weak anti-inflammatory activity and no analgesic activity.

Microwave-assisted one-pot synthesis of antifungal active l-substituted-3, 7- Dialkyl/aryl-4H-pyrazolo[4, 5-f]- [l, 2, 4]triazolo[3, 4-6][l, 3, 4]thiadiazepines using solid support

A simple, efficient and environment-friendly procedure is developed for the synthesis of l-substitued-3, 7-diaikyl/aryl-4H-pyrazolo[4, 5-f][l, 2, 4]triazolo[3, 4-6][l, 3, 4]thiadiazepines 3 by condensation of l-amino-2-mercapto-l, 3, 4-triazoles 1 and 5-chloro-4-formyl-l, 2-pyrazoles 2 in the presence of N,N-dimethyl-formamide as an energy transfer medium, p-TsOH as catalyst and basic alumina as solid support under microwave irradiation. The products are obtained in good to moderate yields and are in a state of high purity.