303752-26-3

Basic information

• Product Name: 5-(4-bromo-phenyl)-1-methyl-piperidin-2-one
• Synonyms: 5-(4-bromo-phenyl)-1-methyl-piperidin-2-one
• CAS NO: 303752-26-3
• Molecular Weight: 268.153
• Mol File: 303752-26-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(4-bromo-phenyl)-1-methyl-piperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-bromo-phenyl)-1-methyl-piperidin-2-one(303752-26-3)
• EPA Substance Registry System: 5-(4-bromo-phenyl)-1-methyl-piperidin-2-one(303752-26-3)

Safety Data

• Hazardous Substances Data: 303752-26-3(Hazardous Substances Data)

Upstream product

• 41216-18-6 1-methyl-5-(4-nitro-phenyl)-piperidin-2-one 
• 32246-05-2 1-methyl-5-phenyl-piperidin-2-one 
• 303752-25-2 5-(4-amino-phenyl)-1-methyl-piperidin-2-one 

Relevant articles and documents

Simple Bi- and tricyclic inhibitors of human steroid 5α-Reductase

A number of tricyclic thiolactams, bicyclic lactams, and bicyclic thiolactams have been prepared and evaluated in vitro as inhibitors of types 1 and 2 steroid 5α-reductase. The tricycles with an 8-chloro substituent in the C-ring are nM (IC50) inhibitors of type 1 steroid 5α-reductase (SR). In all the cases studied, lactams are more potent than the corresponding thiolactams. Activity against type 2 SR is greatly enhanced by a styryl (or azo) substituent on the aryl ring of the tri- and bicycles and also a related tricyclic aryl acid. (C) 2000 Elsevier Science Ltd.