303759-32-2Relevant academic research and scientific papers
Synthesis of a New Series of N-Mannich Bases and Polyhydroxy Mannich Bases of Pharmaceutical Interest Related to Isatin and Its Schiff Bases
Afsah, Elsayed M.,Fadda, Ahmad A.,Hanash, Ahlam H.
, p. 736 - 742 (2018)
The reaction of isatin 1 with benzaldehyde and a sec-amine or the appropriate aldimine afforded the N-Mannich bases 2–3 and the bis-base 4. Treatment of 1 with glutaric dialdehyde and morpholine gave the bis-base 5. Mannich reaction of the Schiff bases 6a–f derived from 1, led to the new Mannich bases and bis-bases 7–9. The use of N-methyl-D-glucamine as the amine component in the Mannich reaction with 6b–f led to the polyhydroxy Mannich bases 11–13.
