303773-37-7

Basic information

• Product Name: C₂₀H₁₅N₃O₃
• CAS NO: 303773-37-7
• Molecular Weight: 345.357
• Mol File: 303773-37-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₅N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₅N₃O₃(303773-37-7)
• EPA Substance Registry System: C₂₀H₁₅N₃O₃(303773-37-7)

Safety Data

• Hazardous Substances Data: 303773-37-7(Hazardous Substances Data)

Upstream product

• 18622-23-6 4-phenylbenzohydrazide 
• 99-61-6 3-nitro-benzaldehyde 
• 720-75-2 methyl 4-phenylbenzoate 
• 92-92-2 biphenyl-4-carboxylic acid 

Downstream Products

• 1320356-59-9 N-[2-(3-nitro-phenyl)-5-benzylidene-4-oxo-thiazolidin-3-yl]biphenyl-4-carboxamide 
• 1320356-60-2 N-[2-(3-nitro-phenyl)-5-(3-nitro-benzylidene)-4-oxothiazolidin-3-yl]biphenyl-4-carboxamide 
• 1320356-61-3 N-[2-(3-nitro-phenyl)-5-(4-chlorobenzylidene)-4-oxothiazolidin-3-yl]biphenyl-4-carboxamide 
• 1222504-85-9 C₂₂H₁₇N₃O₄S 

Relevant articles and documents

Synthesis of 2-(aryl)-5-(arylidene)-4-thiazolidinone derivatives with potential analgesic and anti-inflammatory activity

A series of novel N-[5-(arylidene)-2-(aryl)-4-oxo-thiazolidin-3-yl]-4- biphenylcarboxamide derivatives was synthesized and evaluated for analgesic and anti-inflammatory activity. In this study, biphenyl-4-carboxylic acid hydrazide was converted to the corresponding aryl hydrazones using aryl aldehydes in the presence of catalytic amount of glacial acetic acid. The aryl hydrazones on reaction with thioglycolic acid in the presence of anhydrous zinc chloride yielded N-[2-(aryl)-4-oxo-thiazolidin-3-yl]-4-biphenylcarboxamide which further on reaction with aromatic aldehydes in the presence of anhydrous sodium acetate and glacial acetic acid furnished the title compounds. All compound exhibited anti-inflammatory activity at the dose 10 mg/kg. The structures of all these newly synthesized compounds were confirmed by their elemental analyses (C, H, N) and spectral data (IR and 1H NMR). Springer Science+Business Media, LLC 2011.