30380-70-2

Usage

Uses

Used in Pharmaceutical Industry:
5-OXO-1-(2-PHENYLETHYL)PYRROLIDINE-3-CARBOXYLIC ACID is used as a building block for the synthesis of various bioactive molecules. Its unique structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Drug Discovery and Development:
5-OXO-1-(2-PHENYLETHYL)PYRROLIDINE-3-CARBOXYLIC ACID is used as a starting material for drug discovery and development. Its potential pharmacological properties make it a valuable candidate for further research and exploration in the creation of novel therapeutic agents.
Used in Medicinal Chemistry Research:
5-OXO-1-(2-PHENYLETHYL)PYRROLIDINE-3-CARBOXYLIC ACID is used as a research tool in medicinal chemistry. Scientists can utilize 5-OXO-1-(2-PHENYLETHYL)PYRROLIDINE-3-CARBOXYLIC ACID to study its interactions with biological targets and evaluate its potential as a therapeutic agent.
Used in Chemical Synthesis:
5-OXO-1-(2-PHENYLETHYL)PYRROLIDINE-3-CARBOXYLIC ACID is used in chemical synthesis processes to create a variety of complex organic molecules. Its versatile structure allows for the development of new compounds with potential applications in various fields.

InChI:InChI=1/C13H15NO3/c15-12-8-11(13(16)17)9-14(12)7-6-10-4-2-1-3-5-10/h1-5,11H,6-9H2,(H,16,17)/p-1/t11-/m1/s1

Upstream product

• 97-65-4 2-methylenesuccinic acid 
• 64-04-0 phenethylamine 
• 617-52-7 Dimethyl itakonate 

Downstream Products

• 1015556-37-2 4-(4-benzylpiperazine-1-carbonyl)-1-phenethylpyrrolidin-2-one 
• 29451-88-5 5-oxo-1-phenethyl-pyrrolidine-3-carbonyl chloride 

Relevant academic research and scientific papers

Inhibition of noroviruses by piperazine derivatives

There is currently an unmet need for the development of small-molecule therapeutics for norovirus infection. The piperazine scaffold, a privileged structure embodied in many pharmacological agents, was used to synthesize an array of structurally-diverse derivatives which were screened for anti-norovius activity in a cell-based replicon system. The studies described herein demonstrate for the first time that functionalized piperazine derivatives possess anti-norovirus activity. Furthermore, these studies have led to the identification of two promising compounds (6a and 9l) that can be used as a launching pad for the optimization of potency, cytotoxicity, and drug-like characteristics.

CCR5 antagonists as anti-HIV-1 agents. 1. Synthesis and biological evaluation of 5-oxopyrrolidine-3-carboxamide derivatives

A novel lead compound, N-{3-[4-(4-fluorobenzoyl)piperidin-1-yl]propyl}-1- methyl-5-oxo-N-phenylpyrrolidine-3-carboxamide (1), was identified as a CCR5 antagonist by high-throughput screening using [125I]RANTES and CCR5-expressing CHO cells. The IC50 value of 1 was 1.9 μM. In an effort to improve the binding affinity of 1, a series of 5-oxopyrrolidine-3- carboxamides was synthesized. Introduction of 3,4-dichloro substituents to the central phenyl ring (10i, IC50=0.057 μM; 11b, IC 50=0.050 μM) or replacing the 1-methyl group of the 5-oxopyrrolidine moiety with a 1-benzyl group (12e, IC50=0.038 μM) was found to be effective for improving CCR5 affinity. Compound 10i, 11b, and 12e also inhibited CCR5-using HIV-1 envelope-mediated membrane fusion with IC50 values of 0.44, 0.19, and 0.49 μM, respectively.

CYCLIC AMIDE COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF

A compound of the formula: wherein R1 is a hydrocarbon group, R2 is a hydrocarbon group having 2 or more carbon atoms, where R1 and R2 may in combination form, together with an adjacent nitrogen atom, a ring optionally having a substituent or substituents, R3 is a hydrocarbon group optionally having a substituent or substituents or a heterocyclic group optionally having a substituent or substituents, R4 is a hydrogen atom, a hydrocarbon group, a heterocyclic group and the like, E is a divalent chain hydrocarbon group and the like, G is CO or SO2, J is a nitrogen atom, a methine group and the like, and Q and R are each a divalent chain C1-3 hydrocarbon group and the like, and a salt thereof show a superior CCR5 antagonistic activity and are useful as agents for the prophylaxis or treatment of HIV infection of human peripheral blood mononuclear cells, particularly AIDS.