30389-33-4

Usage

Chemical Properties

Off-white Solid

Uses

Carteolol (C184450) metabolite.

InChI:InChI=1/C9H9NO2/c11-8-3-1-2-7-6(8)4-5-9(12)10-7/h1-3,11H,4-5H2,(H,10,12)

Upstream product

• 21261-76-7 N-(3-methoxyphenyl)-3-chloropropionamide 
• 30557-06-3 3,4-dihydro-5-methoxy-2(1H)-quinolinone 
• 5057-12-5 3,4,7,8-tetrahydro-2,5(1H,6H)-quinolinequinone 

Downstream Products

• 73963-63-0 5-[3-(1-Cyclohexyltetrazol-5-yl)propoxy]-3,4-dihydrocarbostyril 
• 2461-42-9 3-(1-naphthyloxy)-1,2-epoxypropane 
• 51781-13-6 5-(3-chloro-2-hydroxypropoxy)-3,4-dihydrocarbostyril 
• 20133-93-1 1-chloro-3-(1-naphthoxy)-2-propanol 
• 120004-60-6 5-[2-(4-phenyl-piperazin-1-yl)-ethoxy]-3,4-dihydro-1H-quinolin-2-one 
• 76824-56-1 5-{3-[4-(2,3-Dimethyl-phenyl)-piperazin-1-yl]-propoxy}-3,4-dihydro-1H-quinolin-2-one 
• 120004-64-0 5-{3-[4-(5-Chloro-2-methyl-phenyl)-piperazin-1-yl]-propoxy}-3,4-dihydro-1H-quinolin-2-one 
• 120004-63-9 5-{3-[4-(3,4-Dichloro-phenyl)-piperazin-1-yl]-propoxy}-3,4-dihydro-1H-quinolin-2-one 
• 120004-61-7 5-{3-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-propoxy}-3,4-dihydro-1H-quinolin-2-one 
• 120004-62-8 5-{3-[4-(2,5-Dichloro-phenyl)-piperazin-1-yl]-propoxy}-3,4-dihydro-1H-quinolin-2-one 
• 72566-32-6 5-[3-(4-Phenyl-piperazin-1-yl)-propoxy]-3,4-dihydro-1H-quinolin-2-one; hydrochloride 
• 72723-28-5 5-{3-[4-(2-fluoro-phenyl)-piperazin-1-yl]-propoxy}-3,4-dihydro-1H-quinolin-2-one 
• 72723-17-2 5-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propoxy}-3,4-dihydro-1H-quinolin-2-one 
• 72572-01-1 5-{3-[4-(2-ethoxy-phenyl)-piperazin-1-yl]-propoxy}-3,4-dihydro-1H-quinolin-2-one 

Relevant academic research and scientific papers

Stable carteolol hydrochloride, preparation method thereof and eye medicine combination

The invention relates to stable carteolol hydrochloride, a preparation method thereof and an eye medicine combination, in particular to a method for preparing carteolol hydrochloride. The method comprises the following steps of preparing 3-amino-2-cyclohexenone, tetrahydro-2,5(1H, 6H)-quinolinone, 5-hydroxy-3,4-dihydro-2(1H)-carbostyril and 5-(2,3-epoxypropoxy)-3,4-dihydro-2(1H)-carbostyril, and then the carteolol hydrochloride is obtained. Furthermore, the invention provides the carteolol hydrochloride crude medicine obtained according to the method, the eye medicine combination prepared by using the obtained carteolol hydrochloride as the crude medicine, and applications of the obtained carteolol hydrochloride to preparation of drugs for treating or preventing glaucoma or ocular hypertension. The method has excellent pharmaceutical characteristics, for example, the obtained crude medicine and a preparation has excellent stability.

5-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}-2(1H)-quinolinones and 3,4-dihydro-2(1H)-quinolinones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors. Part 3

5-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}-2(1H)-quinolinones and 3,4-dihydro-2(1H)-quinolinones have been identified with different combinations of 5-HT1 autoreceptor antagonist and hSerT potencies and excellent rat PK profiles. The

Processes for preparing 7-hydroxy-3,4-dihydro-2(1H)-quinolinone and the use in aripiprazole preparation thereof

The present invention provides improved processes for preparing the intermediate 7-hydroxy-3,4-dihydro-2(1H)-quinolinone (7-HQ), which may be used in preparing the drug aripiprazole. Among these processes are included three efficient processes for preparing 7-hydroxy-3,4-dihydro-2(1H)-quinolinone comprising reacting N-(3-methoxyphenyl)-3-chloropropionamide with AlCl3 using novel reaction conditions thus obtaining a substantially pure product, which may be used in the subsequent steps for obtaining aripiprazole without further purification.