303952-84-3Relevant academic research and scientific papers
Development of trityl-based photolabile hydroxyl protecting groups
Zhou, Lei,Yang, Haishen,Wang, Pengfei
experimental part, p. 5873 - 5881 (2011/10/02)
A series of trityl-based photolabile hydroxyl protecting groups have been examined. These PPGs evolve from the traditional acid-labile trityl protecting group with proper electron-donating substituents. Structure-reactivity relationships have been explored. A m-dimethylamino group is crucial to achieve high photochemical deprotection efficiency. The o-hydroxyl group in 8 greatly improves the yield of the photochemical deprotection reaction, compared with the corresponding o-methoxyl-substituted counterpart 7. However, comparison between the photoreactions of 9 and 11 does not show similar structural relevance. The PPG in ether 1 (i.e., DMATr group) is structurally simple and easy to prepare and install. Its deprotection can be successfully carried out with irradiation of sunlight without requirement of photochemical devices.
PHOTO-ACTIVATED PROTECTING GROUPS
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Page/Page column 26-28, (2010/04/28)
Novel photo-activated protecting groups, photo-activatable groups, and methods for their synthesis and use are described. The photo-activated protecting groups are useful in making photo-activatable forms, i.e., inactive proforms, of compounds that can be activated in situ, for example, for initiating chemical reactions upon photo-activation or providing an inactive proform of a therapeutic agent to a subject and photo-activating the therapeutic agent at a selected area of the subject. Also disclosed are methods for administering a photo-activatable compound to a subject then activating the compound at a selected area of the subject by exposing that area to light.
Facilitated photochemical cleavage of benzylic C-O bond. Application to photolabile hydroxyl-protecting group design
Wang, Pengfei,Zhou, Lei,Zhang, Xin,Liang, Xing
supporting information; experimental part, p. 1514 - 1516 (2010/06/12)
A new photolabile hydroxyl-protecting group has been developed by introducing a dimethylamino group to the meta position of an aromatic ring of the traditional trityl (Tr) protecting group. The Royal Society of Chemistry 2010.
