303952-84-3Relevant academic research and scientific papers
Development of trityl-based photolabile hydroxyl protecting groups
Zhou, Lei,Yang, Haishen,Wang, Pengfei
experimental part, p. 5873 - 5881 (2011/10/02)
A series of trityl-based photolabile hydroxyl protecting groups have been examined. These PPGs evolve from the traditional acid-labile trityl protecting group with proper electron-donating substituents. Structure-reactivity relationships have been explored. A m-dimethylamino group is crucial to achieve high photochemical deprotection efficiency. The o-hydroxyl group in 8 greatly improves the yield of the photochemical deprotection reaction, compared with the corresponding o-methoxyl-substituted counterpart 7. However, comparison between the photoreactions of 9 and 11 does not show similar structural relevance. The PPG in ether 1 (i.e., DMATr group) is structurally simple and easy to prepare and install. Its deprotection can be successfully carried out with irradiation of sunlight without requirement of photochemical devices.
Facilitated photochemical cleavage of benzylic C-O bond. Application to photolabile hydroxyl-protecting group design
Wang, Pengfei,Zhou, Lei,Zhang, Xin,Liang, Xing
supporting information; experimental part, p. 1514 - 1516 (2010/06/12)
A new photolabile hydroxyl-protecting group has been developed by introducing a dimethylamino group to the meta position of an aromatic ring of the traditional trityl (Tr) protecting group. The Royal Society of Chemistry 2010.
PHOTO-ACTIVATED PROTECTING GROUPS
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Page/Page column 26-28, (2010/04/28)
Novel photo-activated protecting groups, photo-activatable groups, and methods for their synthesis and use are described. The photo-activated protecting groups are useful in making photo-activatable forms, i.e., inactive proforms, of compounds that can be activated in situ, for example, for initiating chemical reactions upon photo-activation or providing an inactive proform of a therapeutic agent to a subject and photo-activating the therapeutic agent at a selected area of the subject. Also disclosed are methods for administering a photo-activatable compound to a subject then activating the compound at a selected area of the subject by exposing that area to light.
