304007-87-2Relevant academic research and scientific papers
5-(20-Pyridyl)-2-aminothiazoles: Alkyl amino sulfonamides and sulfamides as potent NPY5 antagonists
Packiarajan, Mathivanan,Coate, Heather,Desai, Mahesh,Jimenez, Hermogenes N.,Reinhard, Emily J.,Jubian, Vrej J.,Marzabadi, Mohammad R.,Chandrasena, Gamini,Wolinski, Toni C.,Walker, Mary W.,Andersen, Kim
, p. 6500 - 6504 (2011/12/04)
Synthesis, SAR and physico-chemical properties of an alkyl aminothiazole series 8 and 16are described. 2-Pyridylaminothiazole based compounds such as 8c and 16a exhibit high affinity at the NPY5 receptor with desirable cLogPs and solubilities. However, they also suffer fromhigh in vitro and in vivo clearance. Compound 16a partially inhibits the feeding behavior elicited by i.c.v. injection of the selective NPY5 agonist [cPP1-7, NPY19-23, Ala31, Aib32, Gln34]-human pancreatic polypeptide polypeptide (cPP).
