30427-94-2Relevant academic research and scientific papers
Solvent-free palladium-catalyzed C–O cross-coupling of aryl bromides with phenols
Asachenko, Andrey F.,Bogachev, Vasilii N.,Cherkashchenko, Ilia R.,Lavrov, Konstantin V.,Minaeva, Lidiya I.,Nechaev, Mikhail S.,Rzhevskiy, Sergey A.,Sterligov, Grigorii K.,Topchiy, Maxim A.
, p. 409 - 411 (2021/06/07)
A new solvent-free procedure for C–O cross-coupling between phenols and aryl bromides comprising of Pd2(dba)3/ButBrettPhos catalytic system is efficient for substrates bearing donor or acceptor, as well as bulky substituents.
Ligand-free highly effective iron/copper co-catalyzed formation of dimeric aryl ethers or sulfides
Qu, Xiaoming,Li, Tingyi,Zhu, Yan,Sun, Peng,Yang, Hailong,Mao, Jincheng
supporting information; experimental part, p. 5043 - 5046 (2011/08/22)
Highly selective coupling of diiodoarenes with phenols or phenthiols can be performed by using a low-cost, benign character and readily available Fe/Cu catalytic system in the absence of ligands. It is noteworthy that the desired dimeric aryl ethers or sulfides could be obtained in high yields by coupling between diiodoarenes and phenols, or diphenols with aryl iodides. The Royal Society of Chemistry 2011.
Bis(cyclopentadienyliron)arene Complexes: A new route to the synthesis and functionalization of polyaromatic ethers
Abd-El-Aziz, Alaa S.,Schriemer, David C.,De Denus, Christine R.
, p. 374 - 384 (2008/10/08)
A new development in the chemistry of arenes activated toward SNAr reactions by the cyclopentadienyliron (FeCp+) moiety is presented in this work. A class of diiron complexes of diphenoxybenzenes was prepared in a highly efficient and very mild fashion. Dihydroxy aromatic compounds served as dinucleophiles, allowing for the formation of the diiron complexes. This could be achieved in either a one or two step procedure. A wide variety of dinucleophiles were incorporated into this study, as well as a number of FeCp+ activated arenes. It is shown that these reactions are not inhibited by bulky substituents on either the dinucleophiles or activated arenes. The diiron complexes themselves could also undergo SNAr reactions, provided that the complexed arenes contained a chlorine substituent. This allowed for the functionalization of the complexes with species that could not be introduced directly in their syntheses. The carbon nucleophiles generated from ethyl cyanoacetate or (phenylsulfonyl)acetonitrile could be attached to the complexed ethers in this manner. The FeCp+ moieties were removed easily by photolytic demetalation which allowed for the recovery of a wide range of functionalized diphenoxybenzenes. This methodology is advantageous over all those previously reported and should be a practical route to the synthesis of aromatic ethers.
Functionalization of chlorobenzenes via their CpFe+ salts: a synthesis of substituted diphenyl ethers
Cambie, Richard C.,Janssen, Sally J.,Rutledge, Peter S.,Woodgate, Paul D.
, p. 97 - 114 (2007/10/02)
In work directed towards the synthesis of functionalized diaryl ethers such as SK + F L-94901 the benzylic carbanion derived from 3-ethoxy-6-methylpyridazine-1-oxide was added ortho to an electron-withdrawing chloride group in (η5-cyclopentadienyl)(η6-1,4-dichlorobenzene)iron(1+) hexafluorophosphate(1-) and other η6-chloroarene cationic complexes to form neutral η5-cyclohexadienyl ligands.Oxidative aromatization of the adduct occurred with concomitant demetallation.In contrast to the Yanovsky-type reactions of the carbanion, chloride was displaced from (η6-1,4-dichlorobenzene)CpFe+ by phenoxide anions under mild conditions to give η6-diphenyl ether cationic complexes.
