30431-62-0Relevant academic research and scientific papers
Asymmetric synthesis of phenylisopropylamines
-
, (2008/06/13)
The synthesis of enantiomers of a series of methoxy- and alkyl- substituted phenylisopropylamines is described. The synthesis comprises reducing the imines, formed by the reaction of appropriate phenylacetones with either (+)- or (-)-α-methylbenzylamine, by low-pressure reduction techniques, and subsequently subjecting the optically active N-(α-phenethyl)phenylisopropylamine derivative to hydrogenolysis. The hydrogenolysis products are characterized by enantiomeric purities in the range of 96 - 99%. Yields of products are approximately 60%.
Psychotomimetic phenylisopropylamines. 5. 4 alkyl 2,5 dimethoxyphenylisopropylamines
Shulgin,Dyer
, p. 1201 - 1204 (2007/10/06)
A homologous series of 4 alkyl 2,5 dimethoxyphenylisopropylamines (alkyl = H through n C5H11 and t C4H9) was synthesized and compared with mescaline as serotonin agonists in a sheep umbilical preparation. The three carbon homolog 6d was found to be the most potent of the straight chain series in accordance with its observed psychotomimetic effectiveness in man.
